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Fancf Gene Detail
Summary
  • Symbol
    Fancf
  • Name
    Fanconi anemia, complementation group F
  • Feature Type
    protein coding gene
  • IDs
    MGI:3689889
    NCBI Gene: 100040608
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:51510325-51512015 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 32.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3689889
 protein coding gene Chr7:51510325-51512015 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032306
 protein coding gene Chr7:52626026-52627716 (-)
A/J MGP_AJ_G0032285
 protein coding gene Chr7:51793119-51794809 (-)
AKR/J MGP_AKRJ_G0032221
 protein coding gene Chr7:53010336-53012026 (-)
BALB/cJ MGP_BALBcJ_G0032297
 protein coding gene Chr7:51443430-51445120 (-)
C3H/HeJ MGP_C3HHeJ_G0032010
 protein coding gene Chr7:53413779-53415469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032790
 protein coding gene Chr7:54993923-54995613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029797
 protein coding gene Chr7:54809637-54811357 (-)
CAST/EiJ MGP_CASTEiJ_G0031339
 protein coding gene Chr7:44736247-44738690 (-)
CBA/J MGP_CBAJ_G0031975
 protein coding gene Chr7:56852869-56854559 (-)
DBA/2J MGP_DBA2J_G0032132
 protein coding gene Chr7:50972814-50974504 (-)
FVB/NJ MGP_FVBNJ_G0032086
 protein coding gene Chr7:50898145-50899835 (-)
LP/J MGP_LPJ_G0032213
 protein coding gene Chr7:53575671-53577361 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032123
 protein coding gene Chr7:55960070-55961760 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032807
 protein coding gene Chr7:51989028-51990718 (-)
PWK/PhJ MGP_PWKPhJ_G0031059
 protein coding gene Chr7:44277182-44279311 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030900
 protein coding gene Chr7:40146520-40148196 (-)
WSB/EiJ MGP_WSBEiJ_G0031457
 protein coding gene Chr7:52691028-52692718 (-)



Homology
more
  • Human Ortholog
    FANCF, FA complementation group F
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FANCF, FA complementation group F
  • Synonyms
    FAF
  • Links
    NCBI Gene ID: 2188
    neXtProt AC: NX_Q9NPI8
    UniProt: Q9NPI8

  • Chr Location
    11p14.3; chr11:22622533-22625823 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fancf mouse models; 3 with human FANCF associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit small ovaries, abnormal estrous cycle, decreased primordial ovarian follicle number, azoospermia, increased ovary tumor incidence, increased gonadotropin levels, premature death and genomic instability in mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100040608 NCBI Gene Model | MGI Sequence Detail 1691 C57BL/6J ±  kb
    transcript NM_001115087 RefSeq | MGI Sequence Detail 1691 C57BL/6  
    polypeptide E9Q5Z5 UniProt | EBI | MGI Sequence Detail 343 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    References
    more
    • Summaries
      All 20
      Diseases 1
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:156320 Saberwal G, et al., The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation. J Biol Chem. 2009 Nov 27;284(48):33242-54
    • Latest
      J:180025 Bakker ST, et al., Fancf-deficient mice are prone to develop ovarian tumours. J Pathol. 2012 Jan;226(1):28-39
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory