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Sirpa
Gene Detail
 Symbol
Name
ID
Sirpa
signal-regulatory protein alpha
MGI:108563
Synonyms Bit, CD172a, P84, Ptpns1, SHPS-1, SIRP
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.19 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:129592835-129632228 bp, + strand
From VEGA annotation of GRCm38

  39394 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:7246  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: Signal-regulatory protein beta-1
Gene Tree: Sirpa
Human
homologs
Human Homolog SIRPA, signal-regulatory protein alpha
NCBI Gene ID 140885
neXtProt AC  NX_P78324
Human Synonyms  BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Human Chr (Location)  20p13; chr20:1874813-1920540 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(1) : Targeted(1)
 
Homozygous null mice display mild thrombocytopenia, fatty livers, decreased body weight, decreased proportion of single positive T cells, enhanced peritoneal macrophage phagocytosis and impaired Langerhans cell migration.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications 		All GO classifications: (17 annotations)
Process actin filament organization, cell-matrix adhesion, ...
Component integral to membrane, integral to plasma membrane, ...
Function protein binding, protein phosphorylated amino acid binding, ...
External Resources: FuncBase
Expression Literature Summary: (8 records)
Data Summary: Results (94)    Tissues (42)    Images (31)
Theiler Stages: 10, 18, 19, 23, 25, 28
Assay TypeResults
RNA in situ 90
Northern blot 4
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000015506 (Evidence)
Ensembl Gene ModelENSMUSG00000037902 (Evidence)
Entrez Gene19261 (Evidence)
DFCITC1572795, TC1593297
DoTSDT.101379788, DT.533666, DT.94402714
NIA Mouse Gene IndexU002460
PDB2YZ1
Consensus CDS ProjectCCDS16729.1, CCDS50708.1
International Mouse Knockout Project StatusSirpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015506 VEGA Gene Model | MGI Sequence Detail 39394 C57BL/6J ±  kb
transcript OTTMUST00000086795 VEGA | MGI Sequence Detail 3824 Not Applicable 
polypeptide OTTMUSP00000047032 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(6) UniProt(7)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(257 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001968 tyrosine-protein phosphatase non-receptor type substrate 1
References (Earliest) J:36295 Ohnishi H, et al., Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. J Biol Chem. 1996 Oct 11;271(41):25569-74
(Latest) J:191950 Marschinke F, et al., The Absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons. PLoS One. 2012;7(9):e45218
All references(87)
Other
accession IDs 		MGD-MRK-36527, MGD-MRK-37607, MGI:107947, MGI:2139057
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory