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Fzd6
Gene Detail
 Symbol
Name
ID
Fzd6
frizzled homolog 6 (Drosophila)
MGI:108474
Synonyms Fz6
Feature Type protein coding gene
Genetic Map
Chromosome 15
15.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:39006280-39038186 bp, + strand
From Ensembl annotation of GRCm38

  31907 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:2617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd6
Human
homologs
Human Homolog FZD6, frizzled family receptor 6
NCBI Gene ID 8323
neXtProt AC  NX_O60353
Human Synonyms  FZ6, FZ-6, HFZ6, NDNC10
Human Chr (Location)  8q22.3-q23.1; chr8:104310661-104345094 (+)  GRCh37.p10
Disease Associations  (1) Diseases Associated with Human FZD6
Alleles
and
phenotypes 		All alleles(5) : Targeted(5)
 
Homozygous mice for one mutation display abnormal hair follicle orientation. Another mutation of this gene does not appear to result in a phenotype.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (42 annotations)
Process angiogenesis, axonogenesis, ...
Component apical part of cell, apicolateral plasma membrane, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (48 records)
Data Summary: Results (510)    Tissues (296)    Images (112)
Theiler Stages: 1, 2, 3, 4, 5, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 306
In situ reporter (knock in) 99
Northern blot 3
RT-PCR 102
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(24) Genomic(1) cDNA(13) Primer pair(8) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000022297 (Evidence)
Entrez Gene14368 (Evidence)
DFCITC1580206, TC1728399
DoTSDT.101361092, DT.40156000, DT.55156594
NIA Mouse Gene IndexU016198
Consensus CDS ProjectCCDS27441.1
International Mouse Knockout Project StatusFzd6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022297 Ensembl Gene Model | MGI Sequence Detail 31907 C57BL/6J ±  kb
transcript ENSMUST00000179165 Ensembl | MGI Sequence Detail 4077 Not Applicable 
polypeptide ENSMUSP00000136328 Ensembl | MGI Sequence Detail 709 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs(145 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR026543 Frizzled-6
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007722 frizzled-6
References (Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:187523 Nishimura T, et al., Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell. 2012 May 25;149(5):1084-97
All references(87)
Other
accession IDs 		MGD-MRK-37518
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory