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Hyou1
Gene Detail
 Symbol
Name
ID
Hyou1
hypoxia up-regulated 1
MGI:108030
Synonyms 140 kDa, Cab140, CBP-140, Grp170, Orp150
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.84 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:44379490-44392369 bp, + strand
From VEGA annotation of GRCm38

  12880 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:4658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chaperone HSP70
Gene Tree: Hyou1
Human
homologs
Human Homolog HYOU1, hypoxia up-regulated 1
NCBI Gene ID 10525
neXtProt AC  NX_Q9Y4L1
Human Synonyms  Grp170, GRP-170, HSP12A, ORP150, ORP-150
Human Chr (Location)  11q23.1-q23.3; chr11:118914896-118927925 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(7) : Targeted(1) Gene trapped(5) Transgenic(1)
 
Homozygous null mice display embryonic lethality. Heterozygous mice display increased susceptibility to induced neuronal cell death.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (6 annotations)
Process response to hypoxia, response to ischemia, ...
Component endoplasmic reticulum
Function ATP binding, nucleotide binding
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 11, 13, 15
Assay TypeResults
RNA in situ 3
cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(71) cDNA(71)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034194 (Evidence)
Ensembl Gene ModelENSMUSG00000032115 (Evidence)
Entrez Gene12282 (Evidence)
UniGene116721
DFCITC1577113, TC1595940, TC1631139, TC1632209
DoTSDT.101139531, DT.101384635, DT.484735
NIA Mouse Gene IndexU042972
Consensus CDS ProjectCCDS23107.1
International Mouse Knockout Project StatusHyou1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034194 VEGA Gene Model | MGI Sequence Detail 12880 C57BL/6J ±  kb
transcript OTTMUST00000086717 VEGA | MGI Sequence Detail 4489 Not Applicable 
polypeptide OTTMUSP00000046970 VEGA | MGI Sequence Detail 999 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(4)
Polymorphisms SNPs(54 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR018181 Heat shock protein 70, conserved site
InterPro IPR013126 Heat shock protein 70 family
Protein Ontology PR:000008853 hypoxia up-regulated protein 1
Protein Ontology PR:000025325 hypoxia up-regulated protein 1 (mouse)
References (Earliest) J:29304 Naved AF, et al., CBP-140, a novel endoplasmic reticulum resident Ca(2+)-binding protein with a carboxy-terminal NDEL sequence showed partial homology with 70-kDa heat shock protein (hsp70). Cell Struct Funct. 1995 Apr;20(2):133-41
(Latest) J:188135 Tanaka K, et al., Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice. Biochem Biophys Res Commun. 2012 Sep 7;425(4):818-24
All references(47)
Other
accession IDs 		MGD-MRK-37066, MGI:1330846, MGI:2143035
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory