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Npm1
Gene Detail
Symbol

Name
ID
Npm1
nucleophosmin 1
MGI:106184
Synonyms
B23, NO38, nucleolar protein NO38
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:33152287-33163206 bp, - strand
From VEGA annotation of GRCm38

  10920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NPM1
Protein SuperFamily: nucleophosmin
Gene Tree: Npm1

Human
homologs
NPM1, nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4869
neXtProt AC: NX_P06748

Human Synonyms: B23, NPM

Human Chr (Location): 5q35.1; chr5:171387648-171410884 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(37) Targeted(6)
Incidental mutations (data from CvDC )
 
Homozygous mutation of this gene results in embryonic lethality, anemia, defects in primitive hematopoeisis and abnormal brain development. Heterozygous mutation results in hematopoeisis defects and chromosomal instability.
 
Phenotype Images(2)
Interactions
Npm1 interacts with 155 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (100 annotations)
Process cell aging, cell growth, ...
Component cell, centrosome, ...
Function DNA binding, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (56)    Tissues (17)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 7
RT-PCR 36
cDNA source data(1036)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: GEISHA NPM1 ; Xenbase npm1 ; ZFIN npm1a    NEW 
Molecular
reagents
All nucleic(1040) cDNA(1038) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000005395 (Evidence)
Ensembl Gene Model ENSMUSG00000057113 (Evidence)
Entrez Gene 18148 (Evidence)
UniGene 485384
DFCI TC1573652, TC1575434, TC1600773, TC1699334
DoTS DT.102553416, DT.101200099, DT.103581379, DT.94214628, DT.94144570, DT.91372346, DT.55128410, DT.94214485, DT.94214609, DT.94214582, DT.94214573
PDB 4N8M
Consensus CDS Project CCDS24532.1, CCDS56765.1
International Mouse Phenotyping Consortium Status Npm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005395 VEGA Gene Model | MGI Sequence Detail 10920 C57BL/6J ±  kb
transcript OTTMUST00000012025 VEGA | MGI Sequence Detail 1633 Not Applicable 
polypeptide OTTMUSP00000005572 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(6) UniProt(10)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004301 Nucleoplasmin
InterPro IPR024057 Nucleoplasmin core domain
Protein Ontology PR:000011370 nucleophosmin
References
(Earliest) J:13854 Otto J, Submandibular gland esterproteases. Mouse News Lett. 1980;63:12
(Latest) J:218049 Houlihan SL, et al., The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297
All references(97)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory