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Npm1
Gene Detail
 Symbol
Name
ID
Npm1
nucleophosmin 1
MGI:106184
Synonyms B23, NO38, nucleolar protein NO38
Feature Type protein coding gene
Genetic Map
Chromosome 11
19.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:33152287-33163206 bp, - strand
From VEGA annotation of GRCm38

  10920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:81697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nucleophosmin
Gene Tree: Npm1
Human
homologs
Human Homolog NPM1, nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NCBI Gene ID 4869
neXtProt AC  NX_P06748
Human Synonyms  B23, NPM
Human Chr (Location)  5q35.1; chr5:170814708-170837888 (+)  GRCh37.p10
Disease Associations  (1) Diseases Associated with Human NPM1
Alleles
and
phenotypes 		All alleles(42) : Targeted(5) Gene trapped(37)
 
Homozygous mutation of this gene results in embryonic lethality, anemia, defects in primitive hematopoeisis and abnormal brain development. Heterozygous mutation results in hematopoeisis defects and chromosomal instability.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (92 annotations)
Process cell aging, cell growth, ...
Component centrosome, cytoplasm, ...
Function DNA binding, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (22 records)
Data Summary: Results (56)    Tissues (17)    Images (7)
Theiler Stages: 1, 2, 3, 4, 17, 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 7
RT-PCR 36
cDNA source data(1041)
External Resources: GEO   ArrayExpress
Molecular
reagents 		All nucleic(1045) cDNA(1043) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005395 (Evidence)
Ensembl Gene ModelENSMUSG00000057113 (Evidence)
Entrez Gene18148 (Evidence)
UniGene485384
DFCITC1573652, TC1575434, TC1600773, TC1699334
DoTSDT.101200099, DT.102553416, DT.103581379, DT.55128410, DT.91372346, DT.94144570, DT.94214485, DT.94214573, DT.94214582, DT.94214609, DT.94214628
Consensus CDS ProjectCCDS24532.1, CCDS56765.1
International Mouse Knockout Project StatusNpm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005395 VEGA Gene Model | MGI Sequence Detail 10920 C57BL/6J ±  kb
transcript OTTMUST00000012025 VEGA | MGI Sequence Detail 1633 Not Applicable 
polypeptide OTTMUSP00000005572 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(6) UniProt(10)
Polymorphisms SNPs(4 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR004301 Nucleoplasmin
InterPro IPR024057 Nucleoplasmin core domain
Protein Ontology PR:000011370 nucleophosmin
References (Earliest) J:13854 Otto J, Submandibular gland esterproteases. Mouse News Lett. 1980;63:12
(Latest) J:192847 Bhaskaran N, et al., Fbw7alpha and Fbw7gamma collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation. Mol Cell Biol. 2013 Jan;33(1):85-97
All references(90)
Other
accession IDs 		MGD-MRK-33874
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory