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Mxd3
Gene Detail
 Symbol
Name
ID
Mxd3
Max dimerization protein 3
MGI:104987
Synonyms 4631412E13Rik, bHLHc13, Mad3
Feature Type protein coding gene
Genetic Map
Chromosome 13
29.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:55325168-55329758 bp, - strand
From VEGA annotation of GRCm38

  4591 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:32333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: MAX interacting protein
Gene Tree: Mxd3
Human
homologs
Human Homolog MXD3, MAX dimerization protein 3
NCBI Gene ID 83463
neXtProt AC  NX_Q9BW11
Human Synonyms  BHLHC13, MAD3, MYX
Human Chr (Location)  5q35.3; chr5:176732501-176739292 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(14) : Targeted(2) Gene trapped(12)
 
Mice homozygous for disruptions in this gene have an essentially normal phenotype. The show an increased sensitivity to gamma irradiation.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (8 annotations)
Process negative regulation of transcription, DNA-dependent, regulation of transcription, DNA-dependent, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression Literature Summary: (12 records)
Data Summary: Results (184)    Tissues (88)    Images (41)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 19, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 169
RT-PCR 15
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(37) cDNA(35) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020954 (Evidence)
Ensembl Gene ModelENSMUSG00000021485 (Evidence)
Entrez Gene17121 (Evidence)
UniGene20350
DFCITC1582037, TC1738898
DoTSDT.101724287, DT.110956737, DT.531347
NIA Mouse Gene IndexU034811
Consensus CDS ProjectCCDS26543.1
International Mouse Knockout Project StatusMxd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020954 VEGA Gene Model | MGI Sequence Detail 4591 C57BL/6J ±  kb
transcript OTTMUST00000049536 VEGA | MGI Sequence Detail 1327 Not Applicable 
polypeptide OTTMUSP00000022968 VEGA | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs(0 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010791 max dimerization protein 3
References (Earliest) J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
(Latest) J:171624 Machold R, et al., Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59
All references(46)
Other
accession IDs 		MGD-MRK-31060, MGI:2148234
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory