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Rest Gene Detail
Summary
  • Symbol
    Rest
  • Name
    RE1-silencing transcription factor
  • Synonyms
    2610008J04Rik, NRSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104897
    NCBI Gene: 19712
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77413338-77434279 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104897
 protein coding gene Chr5:77413273-77434279 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029656
 protein coding gene Chr5:77523638-77551030 (+)
A/J MGP_AJ_G0029624
 protein coding gene Chr5:74537150-74558134 (+)
AKR/J MGP_AKRJ_G0029572
 protein coding gene Chr5:76985602-77010734 (+)
BALB/cJ MGP_BALBcJ_G0029633
 protein coding gene Chr5:75275747-75296664 (+)
C3H/HeJ MGP_C3HHeJ_G0029356
 protein coding gene Chr5:77345190-77366983 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030087
 protein coding gene Chr5:80609485-80634240 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0028764
 protein coding gene Chr5:76571843-76593730 (+)
CBA/J MGP_CBAJ_G0029325
 protein coding gene Chr5:83289542-83315599 (+)
DBA/2J MGP_DBA2J_G0029470
 protein coding gene Chr5:74594600-74615799 (+)
FVB/NJ MGP_FVBNJ_G0029431
 protein coding gene Chr5:73803802-73825574 (+)
LP/J MGP_LPJ_G0029557
 protein coding gene Chr5:77938647-77961064 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029459
 protein coding gene Chr5:86381223-86404634 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030120
 protein coding gene Chr5:76533692-76556440 (+)
PWK/PhJ MGP_PWKPhJ_G0028487
 protein coding gene Chr5:73619109-73640257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028322
 protein coding gene Chr5:75913810-75936531 (+)
WSB/EiJ MGP_WSBEiJ_G0028844
 protein coding gene Chr5:76860131-76881576 (+)



Homology
more
  • Human Ortholog
    REST, RE1 silencing transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REST, RE1 silencing transcription factor
  • Synonyms
    DFNA27, GINGF5, HGF5, NRSF, WT6, XBR
  • Links
    NCBI Gene ID: 5978
    neXtProt AC: NX_Q13127
    UniProt: Q13127

  • Chr Location
    4q12; chr4:56907876-56966808 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human REST associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 10 alleles in 15 genetic backgrounds
    6 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutation of this gene results in embryonic lethality preceded by growth retardation and abnormal cellular organization in several tissues, including the hindbrain and somites. Mice with conditional deletions exhibit increased apoptosis in affected cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    134
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1014
  • Tissues
    170
  • cDNA Data
    20
  • Literature Summary
    53
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029249 Ensembl Gene Model | MGI Sequence Detail 20942 C57BL/6J ±  kb
    transcript ENSMUST00000080359 Ensembl | MGI Sequence Detail 7004 Not Applicable  
    polypeptide ENSMUSP00000079231 Ensembl | MGI Sequence Detail 1082 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 21
      Primer pair 14
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-29050, MGI:1919377
    References
    more
    • Summaries
      All 190
      Developmental Gene Expression 53
      Gene Ontology 27
      Phenotypes 67
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:343231 Natali G, et al., Conditional knockout of REST/NRSF in excitatory neurons reduces seizure susceptibility to chemical kindling. Front Cell Neurosci. 2023;17:1267609
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory