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Tle4
Gene Detail
 Symbol
Name
ID
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
MGI:104633
Synonyms 5730411M05Rik, Bce1, ESTM13, ESTM14, Grg4
Feature Type protein coding gene
Genetic Map
Chromosome 19
9.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:14448072-14597983 bp, - strand
From NCBI annotation of GRCm38

  149912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:38259  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transducin-like enhancer protein
Gene Tree: Tle4
Human
homologs
Human Homolog TLE4, transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
NCBI Gene ID 7091
neXtProt AC  NX_O60756, NX_Q04727
Human Synonyms  BCE1, BCE-1, ESG, ESG4, E(spI), GRG4
Human Chr (Location)  9q21.31; chr9:82186878-82341656 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(46) : Targeted(1) Gene trapped(45)
Gene Ontology
(GO)
classifications 		All GO classifications: (17 annotations)
Process negative regulation of transcription, DNA-dependent, negative regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function chromatin binding, protein binding, ...
External Resources: FuncBase
Expression Literature Summary: (45 records)
Data Summary: Results (368)    Tissues (155)    Images (50)
Theiler Stages: 2, 3, 11, 12, 14, 15, 17, 19, 20, 21, 22, 23, 24
Assay TypeResults
RNA in situ 330
Western blot 2
RT-PCR 36
cDNA source data(83)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(86) cDNA(83) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024642 (Evidence)
Entrez Gene21888 (Evidence)
UniGene103638
DFCITC1579846, TC1584020, TC1597989, TC1598214, TC1604558, TC1659146, TC1669172
DoTSDT.101257284, DT.101715342, DT.102557535, DT.530699, DT.94263383, DT.94263390, DT.94263407
NIA Mouse Gene IndexU038878
Consensus CDS ProjectCCDS50399.1
International Mouse Knockout Project StatusTle4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21888 NCBI Gene Model | MGI Sequence Detail 149912 C57BL/6J ±  kb
transcript NM_011600 RefSeq | MGI Sequence Detail 4555 C57BL/6 
polypeptide Q62441 UniProt | EBI | MGI Sequence Detail 773 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(7)
Polymorphisms RFLP(1) : SNPs(881 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR005617 Groucho/TLE, N-terminal Q-rich domain
InterPro IPR009146 Groucho/transducin-like enhancer
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000016375 transducin-like enhancer protein 4
Graphical View of Protein Domain Structure
References (Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:190738 Lee PC, et al., SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest. J Cell Biol. 2012 Sep 3;198(5):799-813
All references(85)
Other
accession IDs 		MGD-MRK-26070, MGD-MRK-28129, MGD-MRK-28130, MGI:104835, MGI:104836, MGI:1917740, MGI:1930703, MGI:2147460
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory