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Tnc
Gene Detail
 Symbol
Name
ID
Tnc
tenascin C
MGI:101922
Synonyms C130033P17Rik, cytotactin, hexabrachion, Hxb, tenascin-C, TN, TN-C
Feature Type protein coding gene
Genetic Map
Chromosome 4
34.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr4:63959785-64020725 bp, - strand
From VEGA annotation of GRCm38

  60941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:55636  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 dog

Gene Tree: Tnc
Human
homologs
Human Homolog TNC, tenascin C
NCBI Gene ID 3371
neXtProt AC  NX_P24821
Human Synonyms  150-225, GMEM, GP, HXB, JI, TN, TN-C
Human Chr (Location)  9q33; chr9:117781854-117880536 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(5) : Targeted(5)
 
Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (15 annotations)
Process cell adhesion, mesenchymal-epithelial cell signaling involved in prostate gland development, ...
Component basement membrane, extracellular matrix, ...
Function fibronectin binding, syndecan binding
External Resources: FuncBase
Expression Literature Summary: (108 records)
Data Summary: Results (829)    Tissues (213)    Images (108)
Theiler Stages: 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 72
RNA in situ 566
In situ reporter (knock in) 11
Northern blot 84
Western blot 21
RT-PCR 75
cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(89) Genomic(2) cDNA(59) Primer pair(20) Other(8)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000302 (Evidence)
Ensembl Gene ModelENSMUSG00000028364 (Evidence)
Entrez Gene21923 (Evidence)
DFCITC1573025, TC1588200, TC1601619, TC1638095
DoTSDT.101378344, DT.534569, DT.94314494, DT.94314498
NIA Mouse Gene IndexU025161, U350070
Consensus CDS ProjectCCDS18265.1
International Mouse Knockout Project StatusTnc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000302 VEGA Gene Model | MGI Sequence Detail 60941 C57BL/6J ±  kb
transcript OTTMUST00000000774 VEGA | MGI Sequence Detail 7106 Not Applicable 
polypeptide OTTMUSP00000000342 VEGA | MGI Sequence Detail 2110 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(6)
Polymorphisms RFLP(7) : SNPs(396 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000016471 tenascin
References (Earliest) J:152889 Aufderheide E, et al., Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol. 1987 Jul;105(1):599-608
(Latest) J:192562 Sumioka T, et al., Impaired cornea wound healing in a tenascin C-deficient mouse model. Lab Invest. 2013 Feb;93(2):207-17
All references(230)
Other
accession IDs 		MGD-MRK-11022, MGD-MRK-15040, MGD-MRK-18751, MGI:2140328, MGI:3028077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory