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Cfl1
Gene Detail
 Symbol
Name
ID
Cfl1
cofilin 1, non-muscle
MGI:101757
Synonyms Cof, cofilin
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:5490485-5494029 bp, + strand
From Ensembl annotation of GRCm38

  3545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:99735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: ADF/cofilin
Gene Tree: Cfl1
Human
homologs
Human Homolog CFL1, cofilin 1 (non-muscle)
NCBI Gene ID 1072
neXtProt AC  NX_P23528
Human Synonyms  CFL
Human Chr (Location)  11q13; chr11:65622282-65625804 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(32) : Targeted(5) Gene trapped(26) Chemically induced(1)
 
Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (28 annotations)
Process actin filament depolymerization, actin filament organization, ...
Component actin cytoskeleton, cell leading edge, ...
Function actin binding
External Resources: FuncBase
Expression Literature Summary: (21 records)
Data Summary: Results (42)    Tissues (16)   
Theiler Stages: 1, 2, 3, 4, 5, 20, 22, 24, 26, 28
Assay TypeResults
Immunohistochemistry 10
Western blot 30
RT-PCR 2
cDNA source data(498)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(503) Genomic(1) cDNA(499) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000056201 (Evidence)
Entrez Gene12631 (Evidence)
UniGene329655
DFCITC1573890, TC1595977
International Mouse Knockout Project StatusCfl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056201 Ensembl Gene Model | MGI Sequence Detail 3545 C57BL/6J ±  kb
transcript ENSMUST00000116560 Ensembl | MGI Sequence Detail 1148 Not Applicable 
polypeptide ENSMUSP00000112259 Ensembl | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms SNPs(18 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR017904 ADF/Cofilin/Destrin
Protein Ontology PR:000005385 cofilin-1
References (Earliest) J:10541 Moriyama K, et al., Nucleotide sequence of mouse cofilin cDNA. Nucleic Acids Res. 1990 May 25;18(10):3053
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(69)
Other
accession IDs 		MGD-MRK-18563, MGD-MRK-2048, MGI:2147462
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory