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Abl2 Gene Detail
Summary
  • Symbol
    Abl2
  • Name
    ABL proto-oncogene 2, non-receptor tyrosine kinase
  • Synonyms
    Abll, Arg
  • Feature Type
    protein coding gene
  • IDs
    MGI:87860
    NCBI Gene: 11352
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156386356-156477138 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87860
protein coding gene Chr1:156386160-156477189 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016625
protein coding gene Chr1:161521916-161616484 (+)
A/J MGP_AJ_G0016606
protein coding gene Chr1:155028905-155123980 (+)
AKR/J MGP_AKRJ_G0016572
protein coding gene Chr1:159755868-159856443 (+)
BALB/cJ MGP_BALBcJ_G0016567
protein coding gene Chr1:155525519-155617681 (+)
C3H/HeJ MGP_C3HHeJ_G0016391
protein coding gene Chr1:159887574-159984801 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017028
protein coding gene Chr1:167047589-167149537 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014737
protein coding gene Chr1:147224956-147319253 (+)
CAST/EiJ MGP_CASTEiJ_G0015971
protein coding gene Chr1:159437838-159535108 (+)
CBA/J MGP_CBAJ_G0016366
protein coding gene Chr1:172944033-173058694 (+)
DBA/2J MGP_DBA2J_G0016472
protein coding gene Chr1:153975729-154070255 (+)
FVB/NJ MGP_FVBNJ_G0016470
protein coding gene Chr1:152437320-152528621 (+)
LP/J MGP_LPJ_G0016543
protein coding gene Chr1:162652083-162745292 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016495
protein coding gene Chr1:180487813-180584871 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017064
protein coding gene Chr1:159572683-159669078 (+)
PWK/PhJ MGP_PWKPhJ_G0015757
protein coding gene Chr1:153071866-153164918 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015544
protein coding gene Chr1:158313975-158419021 (+)
WSB/EiJ MGP_WSBEiJ_G0016033
protein coding gene Chr1:159675157-159773053 (+)



Homology
more
  • Human Ortholog
    ABL2, ABL proto-oncogene 2, non-receptor tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABL2, ABL proto-oncogene 2, non-receptor tyrosine kinase
  • Synonyms
    ABLL, ARG
  • Links
    NCBI Gene ID: 27
    neXtProt AC: NX_P42684
    UniProt: P42684

  • Chr Location
    1q25.2; chr1:179099330-179229684 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    33 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene display multiple behavioral abnormalities indicating neuronal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026596 Ensembl Gene Model | MGI Sequence Detail 90783 C57BL/6J ±  kb
    transcript ENSMUST00000027888 Ensembl | MGI Sequence Detail 3549 Not Applicable  
    polypeptide ENSMUSP00000027888 Ensembl | MGI Sequence Detail 1182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1016, MGD-MRK-1391, MGI:2138109
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 10
      Gene Ontology 26
      Phenotypes 32
    • Earliest
      J:8517 Kruh GD, et al., A novel human gene closely related to the abl proto-oncogene. Science. 1986 Dec 19;234(4783):1545-8
    • Latest
      J:327184 Xiao Z, et al., The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine. Front Cell Dev Biol. 2022;10:882994

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory