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Ewsr1 Gene Detail
Summary
  • Symbol
    Ewsr1
  • Name
    Ewing sarcoma breakpoint region 1
  • Synonyms
    Ews
  • Feature Type
    protein coding gene
  • IDs
    MGI:99960
    NCBI Gene: 14030
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5069687-5099099 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.22 cM, cytoband A1-A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99960
protein coding gene Chr11:5069687-5099266 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017996
protein coding gene Chr11:2089780-2122264 (-)
A/J MGP_AJ_G0017969
protein coding gene Chr11:2027756-2059228 (-)
AKR/J MGP_AKRJ_G0017933
protein coding gene Chr11:2122993-2158662 (-)
BALB/cJ MGP_BALBcJ_G0017937
protein coding gene Chr11:1999697-2037227 (-)
C3H/HeJ MGP_C3HHeJ_G0017750
protein coding gene Chr11:2012670-2057480 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018389
protein coding gene Chr11:2161485-2192938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016047
protein coding gene Chr11:1922902-1952846 (-)
CAST/EiJ MGP_CASTEiJ_G0017312
protein coding gene Chr11:1988602-2017860 (-)
CBA/J MGP_CBAJ_G0017725
protein coding gene Chr11:2455299-2495483 (-)
DBA/2J MGP_DBA2J_G0017835
protein coding gene Chr11:1927780-1958274 (-)
FVB/NJ MGP_FVBNJ_G0017827
protein coding gene Chr11:1965860-1998650 (-)
LP/J MGP_LPJ_G0017906
protein coding gene Chr11:2165130-2201048 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017853
protein coding gene Chr11:2086972-2119130 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018429
protein coding gene Chr11:2123249-2158321 (-)
PWK/PhJ MGP_PWKPhJ_G0017092
protein coding gene Chr11:1944456-1976265 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016889
protein coding gene Chr11:2115609-2145385 (-)
WSB/EiJ MGP_WSBEiJ_G0017366
protein coding gene Chr11:1994093-2026785 (-)



Homology
more
  • Human Ortholog
    EWSR1, EWS RNA binding protein 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    EWSR1, EWS RNA binding protein 1
    Orthology source: HGNC
  • Synonyms
    bK984G1.4, EWS, EWS-FLI1
  • Links
    NCBI Gene ID: 2130
    neXtProt AC: NX_Q01844
    UniProt: Q01844

  • Chr Location
    22q12.2; chr22:29268009-29300525 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human EWSR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    60 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit postnatal lethality, defective pre-B cell development, apoptosis of gametes and arrest in gamete maturation due to reduced meiotic recombination leading to infertility, kyphosis, lymphopenia, muscular atrophy, and hypersensitivity to ionizing radiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14030 NCBI Gene Model | MGI Sequence Detail 29413 C57BL/6J ±  kb
    transcript NM_001362618 RefSeq | MGI Sequence Detail 3242 C57BL/6  
    polypeptide Q61545 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 336
      cDNA 330
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16765, MGI:2146130
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:20151 Plougastel B, et al., Cloning and chromosome localization of the mouse Ews gene. Genomics. 1994 Sep 1;23(1):278-81
    • Latest
      J:275085 Fleming JT, et al., Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model. Mol Cancer Res. 2019 May;17(5):1024-1035

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory