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Matk Gene Detail
Summary
  • Symbol
    Matk
  • Name
    megakaryocyte-associated tyrosine kinase
  • Synonyms
    CHK, Csk homologous kinase, HYL, Ntk
  • Feature Type
    protein coding gene
  • IDs
    MGI:99259
    NCBI Gene: 17179
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81088769-81098819 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99259
 protein coding gene Chr10:81088769-81099199 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017545
 protein coding gene Chr10:81956312-81970996 (+)
A/J MGP_AJ_G0017523
 protein coding gene Chr10:79056076-79066970 (+)
AKR/J MGP_AKRJ_G0017484
 protein coding gene Chr10:81229616-81240509 (+)
BALB/cJ MGP_BALBcJ_G0017485
 protein coding gene Chr10:79275246-79285689 (+)
C3H/HeJ MGP_C3HHeJ_G0017308
 protein coding gene Chr10:81323478-81334587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017939
 protein coding gene Chr10:84773503-84784484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015628
 protein coding gene Chr10:75254033-75263936 (+)
CAST/EiJ MGP_CASTEiJ_G0016875
 protein coding gene Chr10:81554032-81564238 (+)
CBA/J MGP_CBAJ_G0017280
 protein coding gene Chr10:88083067-88093564 (+)
DBA/2J MGP_DBA2J_G0017386
 protein coding gene Chr10:78261391-78271847 (+)
FVB/NJ MGP_FVBNJ_G0017380
 protein coding gene Chr10:77507225-77517900 (+)
LP/J MGP_LPJ_G0017457
 protein coding gene Chr10:82410863-82421277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017406
 protein coding gene Chr10:89933610-89945626 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017980
 protein coding gene Chr10:81233298-81246432 (+)
PWK/PhJ MGP_PWKPhJ_G0016656
 protein coding gene Chr10:78153388-78164075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016446
 protein coding gene Chr10:80180103-80190656 (+)
WSB/EiJ MGP_WSBEiJ_G0016935
 protein coding gene Chr10:81262539-81274290 (+)



Homology
more
  • Human Ortholog
    MATK, megakaryocyte-associated tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATK, megakaryocyte-associated tyrosine kinase
  • Synonyms
    CHK, CTK, HHYLTK, HYL, HYLTK, Lsk
  • Links
    NCBI Gene ID: 4145
    neXtProt AC: NX_P42679
    UniProt: P42679

  • Chr Location
    19p13.3; chr19:3777970-3802129 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are viable and fertile and appear normal. Unchallenged mutant mice exhibit no hematopoietic defects. SPKLS cell numbers are elevated. IL-7 induced BM cell proliferation and pre-B cell colony formation are enhanced. Antigen induced IFN-gamma secretion is reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    13
  • cDNA Data
    27
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17179 NCBI Gene Model | MGI Sequence Detail 10051 C57BL/6J ±  kb
    transcript NM_010768 RefSeq | MGI Sequence Detail 1997 C57BL/6  
    polypeptide P41242 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 5
      cDNA 31
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16018
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:289379 Nagy Z, et al., Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice. Blood. 2020 Apr 30;135(18):1574-1587
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory