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Tlx1 Gene Detail
Summary
  • Symbol
    Tlx1
  • Name
    T cell leukemia, homeobox 1
  • Synonyms
    Hox11, Hox-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:98769
    NCBI Gene: 21908
  • Gene Overview
    MyGene.info: TLX1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45150680-45156943 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.45 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98769
protein coding gene Chr19:45150082-45156943 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025185
protein coding gene Chr19:44702991-44709258 (+)
A/J MGP_AJ_G0025162
protein coding gene Chr19:42544489-42550794 (+)
AKR/J MGP_AKRJ_G0025130
protein coding gene Chr19:43914743-43921025 (+)
BALB/cJ MGP_BALBcJ_G0025156
protein coding gene Chr19:42595773-42602033 (+)
C3H/HeJ MGP_C3HHeJ_G0024916
protein coding gene Chr19:44076824-44083093 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025599
protein coding gene Chr19:45807385-45813636 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023013
protein coding gene Chr19:41811672-41817921 (+)
CAST/EiJ MGP_CASTEiJ_G0024381
protein coding gene Chr19:43822486-43828749 (+)
CBA/J MGP_CBAJ_G0024896
protein coding gene Chr19:48119441-48132188 (+)
DBA/2J MGP_DBA2J_G0025028
protein coding gene Chr19:42363693-42369982 (+)
FVB/NJ MGP_FVBNJ_G0024989
protein coding gene Chr19:42135715-42141982 (+)
LP/J MGP_LPJ_G0025114
protein coding gene Chr19:44645035-44651296 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025020
protein coding gene Chr19:47500487-47506809 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025657
protein coding gene Chr19:43987855-43994132 (+)
PWK/PhJ MGP_PWKPhJ_G0024131
protein coding gene Chr19:42287448-42293841 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023934
protein coding gene Chr19:42678080-42684441 (+)
WSB/EiJ MGP_WSBEiJ_G0024451
protein coding gene Chr19:44147862-44154078 (+)



Homology
more
  • Human Ortholog
    TLX1, T cell leukemia homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TLX1, T cell leukemia homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX11, TCL3
  • Links
    NCBI Gene ID: 3195
    neXtProt AC: NX_P31314
    UniProt: P31314

  • Chr Location
    10q24.31; chr10:101130773-101137789 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4031
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TLX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant embryos show cellular disorganization at the site of splenic development and never develop a spleen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025215 Ensembl Gene Model | MGI Sequence Detail 6264 C57BL/6J ±  kb
    transcript ENSMUST00000026236 Ensembl | MGI Sequence Detail 2065 Not Applicable  
    polypeptide ENSMUSP00000026236 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 8
      cDNA 9
      Primer pair 5
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10827, MGD-MRK-15137
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 32
      Gene Ontology 4
      Phenotypes 27
    • Earliest
      J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
    • Latest
      J:264234 Vanden Bempt M, et al., Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2018 Aug 13;34(2):271-285.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory