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Tgm2
Gene Detail
 Symbol
Name
ID
Tgm2
transglutaminase 2, C polypeptide
MGI:98731
Synonyms G[a]h, protein-glutamine gamma-glutamyltransferase, TG2, TGase2, TG C, tissue transglutaminase, tTG, tTGas
Feature Type protein coding gene
Genetic Map
Chromosome 2
78.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:158116402-158146436 bp, - strand
From VEGA annotation of GRCm38

  30035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm2

Human
homologs
Human Homolog TGM2, transglutaminase 2
NCBI Gene ID 7052
neXtProt AC  NX_P21980
Human Synonyms  G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC
Human Chr (Location)  20q12; chr20:38128461-38165298 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology.
 
Human Diseases Modeled Using Mouse Tgm2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tgm2 interacts with 162 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process apoptotic cell clearance, blood vessel remodeling, ...
Component cell, cytoplasm, ...
Function calcium ion binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (516)    Tissues (200)    Images (47)
Theiler Stages: 1, 2, 3, 4, 11, 12, 13, 14, 15, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 395
Northern blot 15
Western blot 14
RT-PCR 92
cDNA source data(203)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(216) Genomic(4) cDNA(204) Primer pair(8)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015888 (Evidence)
Ensembl Gene ModelENSMUSG00000037820 (Evidence)
Entrez Gene21817 (Evidence)
UniGene330731
DFCITC1574009, TC1589261, TC1745888
DoTSDT.101384679, DT.101389366, DT.101739099, DT.94288585, DT.94288607, DT.97416295
NIA Mouse Gene IndexU023589
EC2.3.2.13
Consensus CDS ProjectCCDS16985.1
International Mouse Knockout Project StatusTgm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015888 VEGA Gene Model | MGI Sequence Detail 30035 C57BL/6J ±  kb
transcript OTTMUST00000037773 VEGA | MGI Sequence Detail 3596 Not Applicable 
polypeptide OTTMUSP00000016945 VEGA | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(293 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016293 protein-glutamine gamma-glutamyltransferase 2
References (Earliest) J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
(Latest) J:208172 Yang L, et al., GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res. 2014 Feb 15;74(4):1022-31
All references(116)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-15073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory