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Tbxas1
Gene Detail
 Symbol
Name
ID
Tbxas1
thromboxane A synthase 1, platelet
MGI:98497
Synonyms CYP5, CYP5A1, TXAS, TXS
Feature Type protein coding gene
Genetic Map
Chromosome 6
17.85 cM, cytoband F1-pter
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:38875404-39084585 bp, + strand
From VEGA annotation of GRCm38

  209182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:55549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP3A5
Gene Tree: Tbxas1
Human
homologs
Human Homolog TBXAS1, thromboxane A synthase 1 (platelet)
NCBI Gene ID 6916
neXtProt AC  NX_P24557
Human Synonyms  BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
Human Chr (Location)  7q34-q35; chr7:139478047-139720125 (+)  GRCh37.p10
Disease Associations  (2) Diseases Associated with Human TBXAS1
Alleles
and
phenotypes 		All alleles(4) : Targeted(4)
 
Homozygous null mice display increased bleeding time and decreased platelet response to arachidonic acid.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (22 annotations)
Process cellular chloride ion homeostasis, fatty acid biosynthetic process, ...
Component endoplasmic reticulum, integral to membrane, ...
Function electron carrier activity, heme binding, ...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Results (108)    Tissues (107)    Images (2)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 14
cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(45) Genomic(11) cDNA(30) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034254 (Evidence)
Ensembl Gene ModelENSMUSG00000029925 (Evidence)
Entrez Gene21391 (Evidence)
UniGene4054
DFCITC1582679
DoTSDT.40158754, DT.91363811, DT.94295817
NIA Mouse Gene IndexU006696
EC5.3.99.5
Consensus CDS ProjectCCDS20018.1
International Mouse Knockout Project StatusTbxas1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034254 VEGA Gene Model | MGI Sequence Detail 209182 C57BL/6J ±  kb
transcript OTTMUST00000087034 VEGA | MGI Sequence Detail 1990 Not Applicable 
polypeptide OTTMUSP00000047189 VEGA | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs(661 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000016155 thromboxane-A synthase
References (Earliest) J:13301 Zhang L, et al., Molecular cloning and expression of murine thromboxane synthase. Biochem Biophys Res Commun. 1993 Jul 30;194(2):741-8
(Latest) J:112701 Bailey PJ, et al., A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
All references(36)
Other
accession IDs 		MGD-MRK-14734
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory