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Shc1
Gene Detail
 Symbol
Name
ID
Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296
Synonyms p66, p66shc, ShcA
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:89418443-89430015 bp, + strand
From VEGA annotation of GRCm38

  11573 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:7934  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc1
Human
homologs
Human Homolog SHC1, SHC (Src homology 2 domain containing) transforming protein 1
NCBI Gene ID 6464
neXtProt AC  NX_P29353
Human Synonyms  SHC, SHCA
Human Chr (Location)  1q21; chr1:154934774-154946959 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(77) : Targeted(15) Gene trapped(62)
 
Homozygotes with a targeted mutation of the exon encoding the CH2 region show an extended life span, reduced cellular sensitivity to oxidative stress and UV irradiation, and resistance to diet-induced atherogenesis. Homozygotes lacking all three isoforms die around E11.5 with cardiovascular defects.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (38 annotations)
Process actin cytoskeleton organization, actin cytoskeleton reorganization, ...
Component cytoplasm, endosome membrane, ...
Function ephrin receptor binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Results (25)    Tissues (20)    Images (8)
Theiler Stages: 19, 20, 21, 22, 24, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 2
RT-PCR 10
cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(105) Genomic(1) cDNA(103) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022071 (Evidence)
Ensembl Gene ModelENSMUSG00000042626 (Evidence)
Entrez Gene20416 (Evidence)
UniGene86595
DFCITC1576486, TC1618328, TC1700526
DoTSDT.101180654, DT.101385146, DT.101385152, DT.103563474, DT.110749809, DT.491522
Consensus CDS ProjectCCDS17508.1, CCDS50962.1
International Mouse Knockout Project StatusShc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022071 VEGA Gene Model | MGI Sequence Detail 11573 C57BL/6J ±  kb
transcript OTTMUST00000052404 VEGA | MGI Sequence Detail 2617 Not Applicable 
polypeptide OTTMUSP00000024848 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs(35 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR006019 Phosphotyrosine interaction (PID/PI)
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000003178 shc-transforming protein 1
References (Earliest) J:17164 Pelicci G, et al., A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992 Jul 10;70(1):93-104
(Latest) J:192597 Bock F, et al., Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53
All references(110)
Other
accession IDs 		MGD-MRK-14402
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory