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S100b Gene Detail
Summary
  • Symbol
    S100b
  • Name
    S100 protein, beta polypeptide, neural
  • Feature Type
    protein coding gene
  • IDs
    MGI:98217
    NCBI Gene: 20203
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:76089687-76096993 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.76 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98217
 protein coding gene Chr10:76089670-76097153 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017379
 protein coding gene Chr10:76482078-76489384 (+)
A/J MGP_AJ_G0017356
 protein coding gene Chr10:73843621-73851592 (+)
AKR/J MGP_AKRJ_G0017317
 protein coding gene Chr10:75834548-75841850 (+)
BALB/cJ MGP_BALBcJ_G0017316
 protein coding gene Chr10:74047385-74054680 (+)
C3H/HeJ MGP_C3HHeJ_G0017140
 protein coding gene Chr10:75903981-75911276 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017774
 protein coding gene Chr10:79188299-79195646 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015464
 protein coding gene Chr10:70296912-70304214 (+)
CAST/EiJ MGP_CASTEiJ_G0016710
 protein coding gene Chr10:76220291-76227599 (+)
CBA/J MGP_CBAJ_G0017112
 protein coding gene Chr10:82285304-82292602 (+)
DBA/2J MGP_DBA2J_G0017217
 protein coding gene Chr10:73156238-73163546 (+)
FVB/NJ MGP_FVBNJ_G0017209
 protein coding gene Chr10:72309556-72316861 (+)
LP/J MGP_LPJ_G0017290
 protein coding gene Chr10:76995114-77002425 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017238
 protein coding gene Chr10:84353675-84360969 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017813
 protein coding gene Chr10:75886386-75893681 (+)
PWK/PhJ MGP_PWKPhJ_G0016494
 protein coding gene Chr10:72985186-72992543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016277
 protein coding gene Chr10:75115964-75123236 (+)
WSB/EiJ MGP_WSBEiJ_G0016773
 protein coding gene Chr10:75863957-75871258 (+)



Homology
more
  • Human Ortholog
    S100B, S100 calcium binding protein B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S100B, S100 calcium binding protein B
  • Synonyms
    NEF, S100, S100-B, S100beta
  • Links
    NCBI Gene ID: 6285
    neXtProt AC: NX_P04271
    UniProt: P04271

  • Chr Location
    21q22.3; chr21:46598604-46605208 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human S100B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 4 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit enhanced spatial memory, fear memory, and long-term potentiation in the hippocampal CA1 region, and more rapid and severe seizures as the result of an amygdala kindling paradigm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    194
  • cDNA Data
    21
  • Literature Summary
    267
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033208 Ensembl Gene Model | MGI Sequence Detail 7307 C57BL/6J ±  kb
    transcript ENSMUST00000036387 Ensembl | MGI Sequence Detail 1484 Not Applicable  
    polypeptide ENSMUSP00000047968 Ensembl | MGI Sequence Detail 92 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 17
      cDNA 24
      Primer pair 4
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14269, MGI:2143688
    References
    more
    • Summaries
      All 409
      Developmental Gene Expression 267
      Diseases 2
      Gene Ontology 16
      Phenotypes 63
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346057 Lu D, et al., ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells. Cell Rep. 2024 Feb 24;43(3):113818
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory