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Ptn
Gene Detail
 Symbol
Name
ID
Ptn
pleiotrophin
MGI:97804
Synonyms HB-GAM, HBGF-8, HBNF, heparin-binding growth-associated molecule, heparin-binding growth factor 8, Osf1, Osf-1
Feature Type protein coding gene
Genetic Map
Chromosome 6
15.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr6:36715663-36811361 bp, - strand
From NCBI annotation of GRCm38

  95699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:2117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: pleiotrophin
Gene Tree: Ptn
Human
homologs
Human Homolog PTN, pleiotrophin
NCBI Gene ID 5764
neXtProt AC  NX_P21246
Human Synonyms  HARP, HBGF8, HBNF, NEGF1
Human Chr (Location)  7q33; chr7:136912088-137028546 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(2) : Targeted(2)
 
Homozygous null mice exhibit enhanced long term potentiation, an impairment of spatial learning, and increased anxiety. The brains of mutant mice are morphologically normal.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (10 annotations)
Process bone mineralization, learning, ...
Component endoplasmic reticulum, extracellular region, ...
Function growth factor activity, heparin binding
External Resources: FuncBase
Expression Literature Summary: (22 records)
Data Summary: Results (299)    Tissues (164)    Images (32)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 183
Northern blot 1
RT-PCR 114
cDNA source data(127)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(140) Genomic(4) cDNA(129) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000029838 (Evidence)
Entrez Gene19242 (Evidence)
UniGene279690
DFCITC1571988, TC1588024, TC1596620
DoTSDT.101394455, DT.535225
NIA Mouse Gene IndexU027168
Consensus CDS ProjectCCDS20005.1
International Mouse Knockout Project StatusPtn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19242 NCBI Gene Model | MGI Sequence Detail 95699 C57BL/6J ±  kb
transcript NM_008973 RefSeq | MGI Sequence Detail 2021 C57BL/6 
polypeptide P63089 UniProt | EBI | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(6)
Polymorphisms All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs(587 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR000762 Midkine heparin-binding growth factor
InterPro IPR020092 Midkine heparin-binding growth factor, conserved site
InterPro IPR020090 Midkine heparin-binding growth factor, C-terminal
InterPro IPR020091 Midkine heparin-binding growth factor, disulphide-rich domain
InterPro IPR020089 Midkine heparin-binding growth factor, N-terminal
Protein Ontology PR:000013438 pleiotrophin
Graphical View of Protein Domain Structure
References (Earliest) J:10881 Tezuka K, et al., Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues. Biochem Biophys Res Commun. 1990 Nov 30;173(1):246-51
(Latest) J:182157 Baranek C, et al., Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3546-51
All references(86)
Other
accession IDs 		MGD-MRK-13056, MGD-MRK-13057, MGD-MRK-13672
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory