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Prkar1b
Gene Detail
 Symbol
Name
ID
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
MGI:97759
Synonyms RIbeta
Feature Type protein coding gene
Genetic Map
Chromosome 5
77.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:139017306-139150001 bp, - strand
From VEGA annotation of GRCm38

  132696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:37665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cAMP-dependent protein kinase, regulatory subunit
Gene Tree: Prkar1b
Human
homologs
Human Homolog PRKAR1B, protein kinase, cAMP-dependent, regulatory, type I, beta
NCBI Gene ID 5575
neXtProt AC  NX_P31321
Human Synonyms  PRKAR1
Human Chr (Location)  7p22; chr7:588834-767313 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(3) : Targeted(1) Gene trapped(2)
 
Homozygous null mice have reduced LTD and LTP in specific CNS tracts, but normal neuroanatomy and behavior. Response to pain after inflammation is reduced, concurrent with decreased plasma extravasation during the inflammatory response.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (18 annotations)
Process cell proliferation, learning or memory, ...
Component cAMP-dependent protein kinase complex, cytoplasm, ...
Function cAMP binding, cAMP-dependent protein kinase regulator activity, ...
External Resources: FuncBase
Expression Literature Summary: (7 records)
Data Summary: Results (406)    Tissues (189)    Images (49)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 360
RT-PCR 46
cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(81) Genomic(10) cDNA(69) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000025121 (Evidence)
Ensembl Gene ModelENSMUSG00000025855 (Evidence)
Entrez Gene19085 (Evidence)
UniGene306163
DFCITC1572687
DoTSDT.101355722, DT.110662204, DT.111080807, DT.488133
NIA Mouse Gene IndexU026874
EC2.7.1.37
Consensus CDS ProjectCCDS19803.1
International Mouse Knockout Project StatusPrkar1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025121 VEGA Gene Model | MGI Sequence Detail 132696 C57BL/6J ±  kb
transcript OTTMUST00000061796 VEGA | MGI Sequence Detail 2637 Not Applicable 
polypeptide OTTMUSP00000030390 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(4) UniProt(13)
Polymorphisms RFLP(1) : SNPs(443 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR002373 cAMP/cGMP-dependent protein kinase
InterPro IPR012198 cAMP-dependent protein kinase regulatory subunit
InterPro IPR003117 cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013229 cAMP-dependent protein kinase type I-beta regulatory subunit
References (Earliest) J:39500 Clegg CH, et al., Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3703-7
(Latest) J:188520 Ilouz R, et al., Localization and quaternary structure of the PKA RIbeta holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12443-8
All references(53)
Other
accession IDs 		MGD-MRK-13610, MGI:2140854
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory