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Ntsr1 Gene Detail
Summary
  • Symbol
    Ntsr1
  • Name
    neurotensin receptor 1
  • Synonyms
    NT-1R, NTR1, NTR-1, Ntsr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97386
    NCBI Gene: 18216
  • Gene Overview
    MyGene.info: NTSR1
Location & Maps
more
  • Sequence Map
    Chr2:180499976-180544980 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45005 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NTSR1, neurotensin receptor 1 (high affinity)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NTSR1, neurotensin receptor 1 (high affinity)
    Orthology source: HomoloGene
  • Synonyms
    NTR
  • Links
    NCBI Gene ID: 4923
    neXtProt AC: NX_P30989

  • Chr Location
    20q13; chr20:62708783-62762771 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 6 alleles in 7 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice deficient for this marker have normal baseline prepulse inhibition responses and acoustic startle responses. Mice are heavier, eat more, and have lower body temperatures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016330 VEGA Gene Model | MGI Sequence Detail 45005 C57BL/6J ±  kb
transcript OTTMUST00000039236 VEGA | MGI Sequence Detail 3917 Not Applicable  
polypeptide OTTMUSP00000017536 VEGA | MGI Sequence Detail 424 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    258 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001627 neurotensin receptor type 1
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR003984 Neurotensin receptor
    IPR003985 Neurotensin type 1 receptor
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 9
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12945
References
more
  • Summaries
    All 55
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:18220 Laurent P, et al., Chromosomal localization of mouse and human neurotensin receptor genes. Mamm Genome. 1994 May;5(5):303-6
  • Latest
    J:216582 Bakirtzi K, et al., The Neurotensin-HIF-1alpha-VEGFalpha Axis Orchestrates Hypoxia, Colonic Inflammation, and Intestinal Angiogenesis. Am J Pathol. 2014 Dec;184(12):3405-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory