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Ntrk1 Gene Detail
Summary
  • Symbol
    Ntrk1
  • Name
    neurotrophic tyrosine kinase, receptor, type 1
  • Synonyms
    Tkr, TrkA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97383
    NCBI Gene: 18211
  • Gene Overview
    MyGene.info: NTRK1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87778244-87795162 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.62 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97383
protein coding gene Chr3:87778244-87795242 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027368
protein coding gene Chr3:87902105-87919023 (-)
A/J MGP_AJ_G0027332
protein coding gene Chr3:84919026-84935956 (-)
AKR/J MGP_AKRJ_G0027298
protein coding gene Chr3:86973134-86990054 (-)
BALB/cJ MGP_BALBcJ_G0027341
protein coding gene Chr3:85015256-85032176 (-)
C3H/HeJ MGP_C3HHeJ_G0027084
protein coding gene Chr3:87268729-87285673 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027787
protein coding gene Chr3:91128466-91145384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025140
protein coding gene Chr3:80539165-80556027 (-)
CAST/EiJ MGP_CASTEiJ_G0026531
protein coding gene Chr3:87487482-87504442 (-)
CBA/J MGP_CBAJ_G0027059
protein coding gene Chr3:94206776-94226301 (-)
DBA/2J MGP_DBA2J_G0027195
protein coding gene Chr3:84402389-84419672 (-)
FVB/NJ MGP_FVBNJ_G0027164
protein coding gene Chr3:82682496-82699420 (-)
LP/J MGP_LPJ_G0027303
protein coding gene Chr3:88863277-88881164 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027183
protein coding gene Chr3:100477251-100495030 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027845
protein coding gene Chr3:86748627-86766828 (-)
PWK/PhJ MGP_PWKPhJ_G0026264
protein coding gene Chr3:84206328-84223608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026081
protein coding gene Chr3:85937604-85954588 (-)
WSB/EiJ MGP_WSBEiJ_G0026610
protein coding gene Chr3:87112049-87128991 (-)



Homology
more
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MTC, p140-TrkA, TRK, TRK1, Trk-A, TRKA
  • Links
    NCBI Gene ID: 4914
    neXtProt AC: NX_P04629
    UniProt: P04629

  • Chr Location
    1q23.1; chr1:156815750-156881850 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ntrk1 mouse models; 2 with human NTRK1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 11 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028072 Ensembl Gene Model | MGI Sequence Detail 16919 C57BL/6J ±  kb
    transcript ENSMUST00000029712 Ensembl | MGI Sequence Detail 2588 Not Applicable  
    polypeptide ENSMUSP00000029712 Ensembl | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011469 high affinity nerve growth factor receptor
    • EC
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR020777 Tyrosine-protein kinase, neurotrophic receptor
      IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
      IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 25
      Primer pair 4
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12942, MGD-MRK-15125, MGI:2140079
    References
    more
    • Summaries
      All 356
      Developmental Gene Expression 203
      Diseases 3
      Gene Ontology 23
      Phenotypes 78
    • Earliest
      J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
    • Latest
      J:272890 Wu Z, et al., Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells. Neuron. 2019 Feb 20;101(4):635-647.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory