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Nras Gene Detail
Summary
  • Symbol
    Nras
  • Name
    neuroblastoma ras oncogene
  • Synonyms
    N-ras
  • Feature Type
    protein coding gene
  • IDs
    MGI:97376
    NCBI Gene: 18176
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:102965643-102975230 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.25 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97376
 protein coding gene Chr3:102965601-102975230 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027689
 protein coding gene Chr3:104301306-104310931 (+)
A/J MGP_AJ_G0027648
 protein coding gene Chr3:100987493-100997716 (+)
AKR/J MGP_AKRJ_G0027614
 protein coding gene Chr3:103475372-103484962 (+)
BALB/cJ MGP_BALBcJ_G0027661
 protein coding gene Chr3:100759638-100769537 (+)
C3H/HeJ MGP_C3HHeJ_G0027390
 protein coding gene Chr3:103792115-103810900 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028104
 protein coding gene Chr3:108168617-108179281 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025445
 protein coding gene Chr3:97130016-97141198 (+)
CAST/EiJ MGP_CASTEiJ_G0026847
 protein coding gene Chr3:102910356-102920591 (+)
CBA/J MGP_CBAJ_G0027365
 protein coding gene Chr3:111861092-111871264 (+)
DBA/2J MGP_DBA2J_G0027508
 protein coding gene Chr3:100239417-100253674 (+)
FVB/NJ MGP_FVBNJ_G0027476
 protein coding gene Chr3:98170011-98179533 (+)
LP/J MGP_LPJ_G0027615
 protein coding gene Chr3:105631534-105641176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027505
 protein coding gene Chr3:118025382-118035036 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028159
 protein coding gene Chr3:102981684-102991279 (+)
PWK/PhJ MGP_PWKPhJ_G0026573
 protein coding gene Chr3:99980770-99990950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026395
 protein coding gene Chr3:101073709-101079460 (+)
WSB/EiJ MGP_WSBEiJ_G0026926
 protein coding gene Chr3:103552162-103561788 (+)



Homology
more
  • Human Ortholog
    NRAS, NRAS proto-oncogene, GTPase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRAS, NRAS proto-oncogene, GTPase
  • Synonyms
    ALPS4, CMNS, KRAS, NCMS, N-ras, NRAS1, NS6
  • Links
    NCBI Gene ID: 4893
    neXtProt AC: NX_P01111
    UniProt: P01111

  • Chr Location
    1p13.2; chr1:114704469-114716771 (-)  GRCh38
Human Diseases
more
  • Diseases
    14 with human NRAS associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 9 alleles in 14 genetic backgrounds
    34 phenotypes from multigenic genotypes
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are viable and fertile with no gross morphological or histological abnormalities, or defects in peripheral blood cell populations. Mice homozygous for an LTR insertion in intron 1 exhibit weight loss immune defectsand postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    98
  • cDNA Data
    186
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18176 NCBI Gene Model | MGI Sequence Detail 9588 C57BL/6J ±  kb
    transcript NM_001410509 RefSeq | MGI Sequence Detail 4612 ZRU/MplStud  
    polypeptide P08556 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 209
      Genomic 13
      cDNA 188
      Primer pair 4
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12932, MGI:2139934
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 12
      Phenotypes 95
    • Earliest
      J:261 GREEN MC, The position of luxoid in linkage group II of the mouse. J Hered. 1961 Nov-Dec;52:297-300
    • Latest
      J:343436 Rajagopalan A, et al., A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice. J Clin Invest. 2023 Dec 15;133(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory