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Il1a
Gene Detail
 Symbol
Name
ID
Il1a
interleukin 1 alpha
MGI:96542
Synonyms Il-1a
Feature Type protein coding gene
Genetic Map
Chromosome 2
62.90 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(57)
Sequence Map
Chr2:129299610-129309972 bp, - strand
From VEGA annotation of GRCm38

  10363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-1
Gene Tree: Il1a
Human
homologs
Human Homolog IL1A, interleukin 1, alpha
NCBI Gene ID 3552
neXtProt AC  NX_P01583
Human Synonyms  IL1, IL-1A, IL1-ALPHA, IL1F1
Human Chr (Location)  2q14; chr2:113531492-113542971 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(3) : Targeted(3)
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, development of Th2 helper cell responses and some antibody responses are compromised.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (37 annotations)
Process cellular response to heat, cytokine-mediated signaling pathway, ...
Component cell surface, cytosol, ...
Function copper ion binding, cytokine activity, ...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Results (115)    Tissues (60)   
Theiler Stages: 2, 3, 4, 5, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RT-PCR 110
Nuclease S1 5
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(16) Genomic(2) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015415 (Evidence)
Ensembl Gene ModelENSMUSG00000027399 (Evidence)
Entrez Gene16175 (Evidence)
UniGene15534
DFCITC1585770
DoTSDT.55187969, DT.99645818
Consensus CDS ProjectCCDS16725.1
International Mouse Knockout Project StatusIl1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015415 VEGA Gene Model | MGI Sequence Detail 10363 C57BL/6J ±  kb
transcript OTTMUST00000036603 VEGA | MGI Sequence Detail 1974 Not Applicable 
polypeptide OTTMUSP00000016430 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms RFLP(14) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR003294 Interleukin-1, alpha/beta
InterPro IPR003295 Interleukin-1, alpha IL1A
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003502 Interleukin-1 propeptide
Protein Ontology PR:000001135 interleukin-1 alpha
References (Earliest) J:7660 Lomedico PT, et al., Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature. 1984 Nov 29-Dec 5;312(5993):458-62
(Latest) J:191979 Ramadas RA, et al., IL-36alpha exerts pro-inflammatory effects in the lungs of mice. PLoS One. 2012;7(9):e45784
All references(220)
Other
accession IDs 		MGD-MRK-11351, MGD-MRK-11366
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2013
MGI 5.14 		The Jackson Laboratory