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Med13 Gene Detail
Summary
  • Symbol
    Med13
  • Name
    mediator complex subunit 13
  • Synonyms
    1110067M05Rik, Thrap1, Trap240
  • Feature Type
    protein coding gene
  • IDs
    MGI:3029632
    NCBI Gene: 327987
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86157859-86248422 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3029632
 protein coding gene Chr11:86157859-86248428 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018888
 protein coding gene Chr11:87816157-87908342 (-)
A/J MGP_AJ_G0018855
 protein coding gene Chr11:84435517-84526018 (-)
AKR/J MGP_AKRJ_G0018825
 protein coding gene Chr11:86965813-87058367 (-)
BALB/cJ MGP_BALBcJ_G0018828
 protein coding gene Chr11:84824526-84915127 (-)
C3H/HeJ MGP_C3HHeJ_G0018642
 protein coding gene Chr11:86993681-87085942 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019280
 protein coding gene Chr11:90478130-90573165 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016913
 protein coding gene Chr11:81466377-81560161 (-)
CAST/EiJ MGP_CASTEiJ_G0018197
 protein coding gene Chr11:87651374-87748325 (-)
CBA/J MGP_CBAJ_G0018613
 protein coding gene Chr11:94279138-94375838 (-)
DBA/2J MGP_DBA2J_G0018721
 protein coding gene Chr11:84009895-84100486 (-)
FVB/NJ MGP_FVBNJ_G0018710
 protein coding gene Chr11:83513731-83605042 (-)
LP/J MGP_LPJ_G0018791
 protein coding gene Chr11:88305850-88398837 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018737
 protein coding gene Chr11:94396401-94498483 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019320
 protein coding gene Chr11:87214205-87306109 (-)
PWK/PhJ MGP_PWKPhJ_G0017966
 protein coding gene Chr11:84799991-84892951 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017758
 protein coding gene Chr11:86756308-86850004 (-)
WSB/EiJ MGP_WSBEiJ_G0018248
 protein coding gene Chr11:87087481-87178976 (-)



Homology
more
  • Human Ortholog
    MED13, mediator complex subunit 13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED13, mediator complex subunit 13
  • Synonyms
    ARC250, DRIP250, HSPC221, MRD61, THRAP1, TRAP240
  • Links
    NCBI Gene ID: 9969
    neXtProt AC: NX_Q9UHV7
    UniProt: Q9UHV7

  • Chr Location
    17q23.2; chr17:61942605-62065278 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MED13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele exhibited in the heart exhibit increased susceptibility to obesity and worsened glucose intolerance when fed a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    33
  • cDNA Data
    103
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 327987 NCBI Gene Model | MGI Sequence Detail 90564 C57BL/6J ±  kb
    transcript NM_001080931 RefSeq | MGI Sequence Detail 10540 C57BL/6  
    polypeptide Q5SWW4 UniProt | EBI | MGI Sequence Detail 2171 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 103
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916101
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:317472 Youn DY, et al., The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc). Mol Metab. 2021 Jun;48:101227
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory