GO Annotations Graph

• Symbol: Vcp
• Name: valosin containing protein
• ID: MGI:99919

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	IMP	J:240290
Molecular Function	GO:0043531	ADP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IMP	J:240290
Molecular Function	GO:0005524	ATP binding	IDA	J:220515
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016887	ATP hydrolysis activity	IDA	J:220515
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:155856
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	IBA	J:265628
Molecular Function	GO:1904288	BAT3 complex binding	ISO	J:164563
Molecular Function	GO:0035800	deubiquitinase activator activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:247402
Molecular Function	GO:0042802	identical protein binding	IPI	J:245245
Molecular Function	GO:0042802	identical protein binding	IPI	J:240290
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	IDA	J:220515
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0042288	MHC class I protein binding	IDA	J:220515
Molecular Function	GO:0003676	nucleic acid binding	EXP	J:247402
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	IDA	J:159080
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:220517
Molecular Function	GO:0005515	protein binding	IPI	J:172993
Molecular Function	GO:0005515	protein binding	IPI	J:220510
Molecular Function	GO:0005515	protein binding	IPI	J:221547
Molecular Function	GO:0005515	protein binding	IPI	J:245245
Molecular Function	GO:0005515	protein binding	IPI	J:159067
Molecular Function	GO:0005515	protein binding	IPI	J:215393
Molecular Function	GO:0005515	protein binding	IPI	J:220515
Molecular Function	GO:0005515	protein binding	IPI	J:188543
Molecular Function	GO:0005515	protein binding	IPI	J:274568
Molecular Function	GO:0005515	protein binding	IPI	J:248222
Molecular Function	GO:0005515	protein binding	IPI	J:248232
Molecular Function	GO:0005515	protein binding	IPI	J:201304
Molecular Function	GO:0005515	protein binding	IPI	J:220517
Molecular Function	GO:0005515	protein binding	IPI	J:87334
Molecular Function	GO:0005515	protein binding	IPI	J:145209
Molecular Function	GO:0005515	protein binding	IPI	J:87334
Molecular Function	GO:0005515	protein binding	IPI	J:153239
Molecular Function	GO:0005515	protein binding	IPI	J:88876
Molecular Function	GO:0005515	protein binding	IPI	J:208390
Molecular Function	GO:0005515	protein binding	IPI	J:96950
Molecular Function	GO:0005515	protein binding	IPI	J:96950
Molecular Function	GO:0005515	protein binding	IPI	J:177751
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:81362
Molecular Function	GO:0005515	protein binding	IPI	J:133467
Molecular Function	GO:0005515	protein binding	IPI	J:72860
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0140036	ubiquitin-dependent protein binding	ISO	J:164563
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	ISO	J:164563
Molecular Function	GO:1990381	ubiquitin-specific protease binding	ISO	J:164563
Molecular Function	GO:1990381	ubiquitin-specific protease binding	IPI	J:221559
Cellular Component	GO:1904949	ATPase complex	IMP	J:240290
Cellular Component	GO:0005737	cytoplasm	NAS	J:88876
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0010494	cytoplasmic stress granule	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646345
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646359
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:200660
Cellular Component	GO:0036513	Derlin-1 retrotranslocation complex	ISO	J:164563
Cellular Component	GO:0036513	Derlin-1 retrotranslocation complex	IDA	J:159067
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:220515
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005811	lipid droplet	ISO	J:73065
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0000502	proteasome complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IPI	J:125219
Cellular Component	GO:0032991	protein-containing complex	IPI	J:125219
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:263386
Cellular Component	GO:0045202	synapse	EXP	J:263386
Cellular Component	GO:0045202	synapse	EXP	J:182391
Cellular Component	GO:0045202	synapse	IDA	J:182391
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	ISO	J:155856
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	ISO	J:164563
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	EXP	J:245245
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	IPI	J:220515
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	IDA	J:220517
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	IDA	J:221559
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	IBA	J:265628
Cellular Component	GO:1990730	VCP-NSFL1C complex	IPI	J:220517
Cellular Component	GO:1990730	VCP-NSFL1C complex	IPI	J:220515
Cellular Component	GO:1990730	VCP-NSFL1C complex	IPI	J:88876
Cellular Component	GO:1990730	VCP-NSFL1C complex	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:87334
Biological Process	GO:0070842	aggresome assembly	IGI	J:111173
Biological Process	GO:0046034	ATP metabolic process	IDA	J:220515
Biological Process	GO:0097352	autophagosome maturation	ISO	J:164563
Biological Process	GO:0097352	autophagosome maturation	IBA	J:265628
Biological Process	GO:0006914	autophagy	ISO	J:164563
Biological Process	GO:1903843	cellular response to arsenite ion	ISO	J:164563
Biological Process	GO:0034605	cellular response to heat	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0061857	endoplasmic reticulum stress-induced pre-emptive quality control	ISO	J:164563
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	ISO	J:155856
Biological Process	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	ISO	J:164563
Biological Process	GO:0071712	ER-associated misfolded protein catabolic process	ISO	J:164563
Biological Process	GO:0071712	ER-associated misfolded protein catabolic process	IBA	J:265628
Biological Process	GO:0036503	ERAD pathway	ISO	J:164563
Biological Process	GO:0072389	flavin adenine dinucleotide catabolic process	ISO	J:164563
Biological Process	GO:0016236	macroautophagy	ISO	J:164563
Biological Process	GO:0051228	mitotic spindle disassembly	IBA	J:265628
Biological Process	GO:0006734	NADH metabolic process	ISO	J:164563
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	ISO	J:164563
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:1903007	positive regulation of Lys63-specific deubiquitinase activity	ISO	J:164563
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	IMP	J:222672
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:1903862	positive regulation of oxidative phosphorylation	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:1903006	positive regulation of protein K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	ISO	J:155856
Biological Process	GO:0010498	proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:233169
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0106300	protein-DNA covalent cross-linking repair	ISO	J:164563
Biological Process	GO:1903715	regulation of aerobic respiration	ISO	J:164563
Biological Process	GO:1905634	regulation of protein localization to chromatin	ISO	J:164563
Biological Process	GO:0050807	regulation of synapse organization	ISO	J:155856
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	ISO	J:155856
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	ISO	J:164563
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	IMP	J:220515
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	EXP	J:220515
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	IBA	J:265628
Biological Process	GO:0035617	stress granule disassembly	ISO	J:164563
Biological Process	GO:0019985	translesion synthesis	ISO	J:164563
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	EXP	J:220515
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	ISO	J:155856
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	ISO	J:164563
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IGI	J:111173
Biological Process	GO:0019079	viral genome replication	ISO	J:164563