GO Annotations Graph

• Symbol: Mef2c
• Name: myocyte enhancer factor 2C
• ID: MGI:99458

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:172163
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:100494
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:162523
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:87788
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:210949
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:33568
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:158762
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:129041
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:17643
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:129041
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:77997
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:173609
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:129167
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:129167
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:122483
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:122483
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:152667
Molecular Function	GO:0042826	histone deacetylase binding	IBA	J:265628
Molecular Function	GO:0071837	HMG box domain binding	IPI	J:175110
Molecular Function	GO:0071837	HMG box domain binding	IPI	J:173609
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:111229
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:175200
Molecular Function	GO:0005515	protein binding	IPI	J:159054
Molecular Function	GO:0005515	protein binding	IPI	J:197686
Molecular Function	GO:0005515	protein binding	IPI	J:144071
Molecular Function	GO:0005515	protein binding	IPI	J:77997
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:210949
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:33568
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:158762
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:167965
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:98506
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:173154
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:173609
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:119152
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:169209
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021975
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:175184
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:175110
Cellular Component	GO:0005634	nucleus	IDA	J:158762
Cellular Component	GO:0005634	nucleus	IDA	J:173609
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IC	J:77997
Cellular Component	GO:0005634	nucleus	IDA	J:161038
Cellular Component	GO:0005634	nucleus	IDA	J:172163
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0030017	sarcomere	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0001782	B cell homeostasis	IMP	J:148288
Biological Process	GO:0042100	B cell proliferation	IMP	J:136292
Biological Process	GO:0050853	B cell receptor signaling pathway	IMP	J:144071
Biological Process	GO:0001568	blood vessel development	IMP	J:119152
Biological Process	GO:0001568	blood vessel development	IMP	J:50309
Biological Process	GO:0001568	blood vessel development	IMP	J:119152
Biological Process	GO:0001568	blood vessel development	IMP	J:50309
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:40724
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:56426
Biological Process	GO:0055007	cardiac muscle cell differentiation	NAS	J:173154
Biological Process	GO:0055007	cardiac muscle cell differentiation	IGI	J:167933
Biological Process	GO:0055007	cardiac muscle cell differentiation	IGI	J:167933
Biological Process	GO:0055007	cardiac muscle cell differentiation	IGI	J:142102
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IMP	J:58218
Biological Process	GO:0003211	cardiac ventricle formation	IMP	J:144407
Biological Process	GO:0003211	cardiac ventricle formation	IGI	J:142102
Biological Process	GO:0060536	cartilage morphogenesis	IMP	J:122483
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0045165	cell fate commitment	IMP	J:146135
Biological Process	GO:0048667	cell morphogenesis involved in neuron differentiation	IMP	J:138189
Biological Process	GO:0071838	cell proliferation in bone marrow	IGI	J:140009
Biological Process	GO:0071838	cell proliferation in bone marrow	IGI	J:140009
Biological Process	GO:0071277	cellular response to calcium ion	IDA	J:175184
Biological Process	GO:0071498	cellular response to fluid shear stress	IDA	J:158762
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:155856
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:144071
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus	ISO	J:164563
Biological Process	GO:0071300	cellular response to retinoic acid	ISO	J:155856
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0035984	cellular response to trichostatin A	IDA	J:158762
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:175177
Biological Process	GO:0002062	chondrocyte differentiation	IGI	J:119152
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IGI	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IGI	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IMP	J:122483
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	IMP	J:122483
Biological Process	GO:0001958	endochondral ossification	IGI	J:119152
Biological Process	GO:0001958	endochondral ossification	IMP	J:119152
Biological Process	GO:0001958	endochondral ossification	IMP	J:119152
Biological Process	GO:0001958	endochondral ossification	IMP	J:119152
Biological Process	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis	IMP	J:158762
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:138188
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:138189
Biological Process	GO:0010467	gene expression	IMP	J:274700
Biological Process	GO:0010467	gene expression	IMP	J:274700
Biological Process	GO:0002467	germinal center formation	IMP	J:144071
Biological Process	GO:0072102	glomerulus morphogenesis	IMP	J:158762
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:50309
Biological Process	GO:0007507	heart development	IMP	J:56426
Biological Process	GO:0007507	heart development	IMP	J:56426
Biological Process	GO:0007507	heart development	IMP	J:56426
Biological Process	GO:0007507	heart development	IMP	J:56426
Biological Process	GO:0007507	heart development	IMP	J:56426
Biological Process	GO:0001947	heart looping	IMP	J:144407
Biological Process	GO:0006959	humoral immune response	IMP	J:144071
Biological Process	GO:0007611	learning or memory	IMP	J:138189
Biological Process	GO:0007611	learning or memory	IMP	J:138188
Biological Process	GO:0000165	MAPK cascade	IMP	J:144071
Biological Process	GO:0000165	MAPK cascade	IDA	J:175200
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:173609
Biological Process	GO:0030224	monocyte differentiation	IMP	J:134352
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007521	muscle cell fate determination	IMP	J:127416
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:158762
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:144407
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:175155
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:28974
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	ISO	J:164563
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0072160	nephron tubule epithelial cell differentiation	IMP	J:158762
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0014033	neural crest cell differentiation	IMP	J:173609
Biological Process	GO:0048666	neuron development	IMP	J:138189
Biological Process	GO:0030182	neuron differentiation	IMP	J:138189
Biological Process	GO:0001764	neuron migration	IMP	J:138189
Biological Process	GO:0001649	osteoblast differentiation	IEP	J:175375
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:119152
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:142102
Biological Process	GO:0030220	platelet formation	IMP	J:148288
Biological Process	GO:0010694	positive regulation of alkaline phosphatase activity	IMP	J:175375
Biological Process	GO:0030890	positive regulation of B cell proliferation	IMP	J:144071
Biological Process	GO:2000987	positive regulation of behavioral fear response	IMP	J:175155
Biological Process	GO:0030501	positive regulation of bone mineralization	IMP	J:175375
Biological Process	GO:2000727	positive regulation of cardiac muscle cell differentiation	ISO	J:164563
Biological Process	GO:2000727	positive regulation of cardiac muscle cell differentiation	IMP	J:144407
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:144407
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:155856
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	IGI	J:140009
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175200
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175110
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:173609
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:50069
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:40724
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:175375
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:144407
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:175155
Biological Process	GO:2000111	positive regulation of macrophage apoptotic process	IMP	J:175177
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0045663	positive regulation of myoblast differentiation	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:175155
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:175375
Biological Process	GO:2001016	positive regulation of skeletal muscle cell differentiation	ISO	J:164563
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:210949
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:158762
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:98506
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:33568
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:36282
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:97509
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:97509
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:129167
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:127114
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:119152
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:36282
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:129167
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:119152
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:122483
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:97509
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:172163
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:122483
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:111229
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162523
Biological Process	GO:0003138	primary heart field specification	IMP	J:144407
Biological Process	GO:2000311	regulation of AMPA receptor activity	IMP	J:138188
Biological Process	GO:0060998	regulation of dendritic spine development	IMP	J:138188
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:77997
Biological Process	GO:0002634	regulation of germinal center formation	IMP	J:136292
Biological Process	GO:0045652	regulation of megakaryocyte differentiation	IMP	J:148288
Biological Process	GO:0043523	regulation of neuron apoptotic process	IMP	J:207812
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IMP	J:138188
Biological Process	GO:2000310	regulation of NMDA receptor activity	IMP	J:138188
Biological Process	GO:0060297	regulation of sarcomere organization	IMP	J:129041
Biological Process	GO:0051963	regulation of synapse assembly	IMP	J:138188
Biological Process	GO:0060025	regulation of synaptic activity	IMP	J:138189
Biological Process	GO:0060025	regulation of synaptic activity	IMP	J:207812
Biological Process	GO:0060025	regulation of synaptic activity	IMP	J:138188
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:207812
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IMP	J:138188
Biological Process	GO:0061333	renal tubule morphogenesis	IMP	J:158762
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0060021	roof of mouth development	IGI	J:122483
Biological Process	GO:0060021	roof of mouth development	IGI	J:122483
Biological Process	GO:0003139	secondary heart field specification	IMP	J:98506
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:0003185	sinoatrial valve morphogenesis	IMP	J:144407
Biological Process	GO:0035914	skeletal muscle cell differentiation	NAS	J:173154
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:127416
Biological Process	GO:0051145	smooth muscle cell differentiation	IMP	J:50309
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0060290	transdifferentiation	ISO	J:155856
Biological Process	GO:0055012	ventricular cardiac muscle cell differentiation	IMP	J:144407