GO Annotations Graph

• Symbol: Tyms
• Name: thymidylate synthase
• ID: MGI:98878

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005542	folic acid binding	ISO	J:155856
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0008168	methyltransferase activity	IEA	J:60000
Molecular Function	GO:0003729	mRNA binding	ISO	J:155856
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:1990825	sequence-specific mRNA binding	ISO	J:164563
Molecular Function	GO:0004799	thymidylate synthase activity	ISO	J:155856
Molecular Function	GO:0004799	thymidylate synthase activity	ISO	J:164563
Molecular Function	GO:0004799	thymidylate synthase activity	IBA	J:265628
Molecular Function	GO:0004799	thymidylate synthase activity	IDA	J:178838
Molecular Function	GO:0004799	thymidylate synthase activity	IDA	J:178838
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0016741	transferase activity, transferring one-carbon groups	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:178838
Cellular Component	GO:0005634	nucleus	IDA	J:150202
Biological Process	GO:0006231	dTMP biosynthetic process	ISO	J:155856
Biological Process	GO:0006231	dTMP biosynthetic process	ISO	J:164563
Biological Process	GO:0006231	dTMP biosynthetic process	IBA	J:265628
Biological Process	GO:0006231	dTMP biosynthetic process	IDA	J:178838
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:0009165	nucleotide biosynthetic process	IEA	J:60000
Biological Process	GO:0006417	regulation of translation	ISO	J:155856
Biological Process	GO:0035999	tetrahydrofolate interconversion	ISO	J:164563
Biological Process	GO:0035999	tetrahydrofolate interconversion	IDA	J:178838