GO Annotations Graph

• Symbol: Trh
• Name: thyrotropin releasing hormone
• ID: MGI:98823

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005179	hormone activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:74954
Molecular Function	GO:0008437	thyrotropin-releasing hormone activity	ISO	J:155856
Molecular Function	GO:0008437	thyrotropin-releasing hormone activity	IBA	J:265628
Molecular Function	GO:0008437	thyrotropin-releasing hormone activity	ISO	J:1296
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IBA	J:265628
Biological Process	GO:0007628	adult walking behavior	IGI	J:36184
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0042755	eating behavior	IBA	J:265628
Biological Process	GO:0001692	histamine metabolic process	ISO	J:155856
Biological Process	GO:0001692	histamine metabolic process	IBA	J:265628
Biological Process	GO:0009755	hormone-mediated signaling pathway	IEA	J:72247
Biological Process	GO:2000252	negative regulation of feeding behavior	ISO	J:155856
Biological Process	GO:0014050	negative regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:0014050	negative regulation of glutamate secretion	IBA	J:265628
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	ISO	J:155856
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	IBA	J:265628
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	IBA	J:265628