GO Annotations Graph

• Symbol: Top1
• Name: topoisomerase (DNA) I
• ID: MGI:98788

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0008301	DNA binding, bending	ISO	J:164563
Molecular Function	GO:0003916	DNA topoisomerase activity	IEA	J:60000
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	ISO	J:155856
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	ISO	J:164563
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA	J:265628
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:39389
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:104607
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:104607
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:104607
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:104607
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:104607
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:22850
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	J:39389
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0097100	supercoiled DNA binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IDA	J:104607
Cellular Component	GO:0005737	cytoplasm	IDA	J:104607
Cellular Component	GO:0005737	cytoplasm	IDA	J:104607
Cellular Component	GO:0005737	cytoplasm	IDA	J:104607
Cellular Component	GO:0005737	cytoplasm	IDA	J:104607
Cellular Component	GO:0001651	dense fibrillar component	ISO	J:155856
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:155856
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:39389
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:39389
Cellular Component	GO:0000228	nuclear chromosome	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:36546
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0005634	nucleus	IDA	J:104607
Cellular Component	GO:0000932	P-body	ISO	J:164563
Cellular Component	GO:0043204	perikaryon	IDA	J:104607
Cellular Component	GO:0043204	perikaryon	IDA	J:104607
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0007059	chromosome segregation	IBA	J:265628
Biological Process	GO:0032922	circadian regulation of gene expression	ISO	J:164563
Biological Process	GO:0006260	DNA replication	IBA	J:265628
Biological Process	GO:0006260	DNA replication	IMP	J:73919
Biological Process	GO:0006265	DNA topological change	ISO	J:155856
Biological Process	GO:0006265	DNA topological change	ISO	J:164563
Biological Process	GO:0006265	DNA topological change	IBA	J:265628
Biological Process	GO:0006265	DNA topological change	IDA	J:104607
Biological Process	GO:0006265	DNA topological change	IDA	J:22850
Biological Process	GO:0040016	embryonic cleavage	IMP	J:36546
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0009303	rRNA transcription	ISO	J:155856