GO Annotations Graph

• Symbol: Tgfb3
• Name: transforming growth factor, beta 3
• ID: MGI:98727

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:248781
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	IEA	J:72247
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	IBA	J:265628
Molecular Function	GO:0034714	type III transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0034714	type III transforming growth factor beta receptor binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IDA	J:69420
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0099126	transforming growth factor beta complex	ISO	J:164563
Cellular Component	GO:0070021	transforming growth factor beta ligand-receptor complex	ISO	J:164563
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:87413
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IDA	J:84447
Biological Process	GO:0045216	cell-cell junction organization	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:21055
Biological Process	GO:0070483	detection of hypoxia	ISO	J:164563
Biological Process	GO:0009790	embryo development	IMP	J:87407
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	ISO	J:155856
Biological Process	GO:0050673	epithelial cell proliferation	IDA	J:84447
Biological Process	GO:0060325	face morphogenesis	IEP	J:136394
Biological Process	GO:0060325	face morphogenesis	ISO	J:164563
Biological Process	GO:0046847	filopodium assembly	IMP	J:119289
Biological Process	GO:0010467	gene expression	IMP	J:108225
Biological Process	GO:0001701	in utero embryonic development	IMP	J:87407
Biological Process	GO:0048286	lung alveolus development	IMP	J:29902
Biological Process	GO:0030879	mammary gland development	IDA	J:1988
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IDA	J:84447
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:117465
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:117465
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:119289
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:87103
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:87103
Biological Process	GO:0051491	positive regulation of filopodium assembly	IMP	J:119289
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:224732
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP	J:87103
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	IMP	J:87103
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1905075	positive regulation of tight junction disassembly	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0032570	response to progesterone	ISO	J:164563
Biological Process	GO:0060021	roof of mouth development	IMP	J:108225
Biological Process	GO:0062009	secondary palate development	IMP	J:248781
Biological Process	GO:0062009	secondary palate development	IMP	J:87103
Biological Process	GO:0062009	secondary palate development	IMP	J:29901
Biological Process	GO:0062009	secondary palate development	IMP	J:29902
Biological Process	GO:0062009	secondary palate development	IMP	J:56561
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628