GO Annotations Graph

• Symbol: Tcf4
• Name: transcription factor 4
• ID: MGI:98506

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:207231
Molecular Function	GO:0003677	DNA binding	ISO	J:73065
Molecular Function	GO:0003677	DNA binding	IDA	J:87788
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:38018
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:38018
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0070888	E-box binding	IDA	J:38018
Molecular Function	GO:0070888	E-box binding	IDA	J:134786
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:125313
Molecular Function	GO:0005515	protein binding	IPI	J:200299
Molecular Function	GO:0005515	protein binding	IPI	J:166757
Molecular Function	GO:0005515	protein binding	IPI	J:38665
Molecular Function	GO:0005515	protein binding	IPI	J:92533
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:160230
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0005515	protein binding	IPI	J:134786
Molecular Function	GO:0005515	protein binding	IPI	J:38665
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0005515	protein binding	IPI	J:160230
Molecular Function	GO:0005515	protein binding	IPI	J:186636
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:134786
Molecular Function	GO:0043621	protein self-association	IMP	J:160230
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:38018
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:201786
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0001093	TFIIB-class transcription factor binding	IDA	J:38018
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:38665
Cellular Component	GO:1990907	beta-catenin-TCF complex	ISO	J:164563
Cellular Component	GO:0070369	beta-catenin-TCF7L2 complex	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:160230
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:38018
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:92533
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0042118	endothelial cell activation	IDA	J:160230
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0016525	negative regulation of angiogenesis	IDA	J:160230
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:160230
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:112802
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:134786
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:38018
Biological Process	GO:0065004	protein-DNA complex assembly	IDA	J:38018
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:92533
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	IDA	J:160230