GO Annotations Graph

• Symbol: Sos1
• Name: SOS Ras/Rac guanine nucleotide exchange factor 1
• ID: MGI:98354

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EXP	J:266120
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EXP	J:102491
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EXP	J:105055
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	Reactome:R-MMU-9682572
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:265276
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:326631
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:265276
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:326631
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:326914
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:196125
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:327223
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:327223
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:100216
Molecular Function	GO:0005515	protein binding	IPI	J:190009
Molecular Function	GO:0005515	protein binding	IPI	J:200431
Molecular Function	GO:0005515	protein binding	IPI	J:196125
Molecular Function	GO:0005515	protein binding	IPI	J:200318
Molecular Function	GO:0005515	protein binding	IPI	J:200364
Molecular Function	GO:0005515	protein binding	IPI	J:200311
Molecular Function	GO:0005515	protein binding	IPI	J:206901
Molecular Function	GO:0005515	protein binding	IPI	J:201945
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:31423
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:40779
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0046982	protein heterodimerization activity	IEA	J:72247
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029146
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029152
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682572
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763903
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9764150
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1250468
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1250472
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1250475
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1250500
Cellular Component	GO:1905360	GTPase complex	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Biological Process	GO:0001782	B cell homeostasis	IGI	J:206090
Biological Process	GO:0050853	B cell receptor signaling pathway	IGI	J:206090
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:38321
Biological Process	GO:0003209	cardiac atrium morphogenesis	IMP	J:38321
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:38321
Biological Process	GO:0061029	eyelid development in camera-type eye	IGI	J:38321
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0001942	hair follicle development	IGI	J:38321
Biological Process	GO:0003007	heart morphogenesis	IMP	J:38321
Biological Process	GO:0061384	heart trabecula morphogenesis	IMP	J:38321
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:327224
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:326913
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:327224
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:307414
Biological Process	GO:0002260	lymphocyte homeostasis	IGI	J:206090
Biological Process	GO:1904693	midbrain morphogenesis	IMP	J:38321
Biological Process	GO:0035264	multicellular organism growth	IMP	J:38321
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	ISO	J:155856
Biological Process	GO:0003344	pericardium morphogenesis	IMP	J:38321
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	TAS	J:76551
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	ISO	J:155856
Biological Process	GO:0007265	Ras protein signal transduction	ISO	J:155856
Biological Process	GO:0007265	Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0043405	regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:2000973	regulation of pro-B cell differentiation	IGI	J:206090
Biological Process	GO:0033081	regulation of T cell differentiation in thymus	IGI	J:206090
Biological Process	GO:0042129	regulation of T cell proliferation	IGI	J:206090
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0060021	roof of mouth development	IMP	J:38321
Biological Process	GO:0007264	small GTPase mediated signal transduction	IMP	J:100216
Biological Process	GO:0007296	vitellogenesis	IMP	J:38321