GO Annotations Graph

• Symbol: Srsf1
• Name: serine and arginine-rich splicing factor 1
• ID: MGI:98283

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0044547	DNA topoisomerase binding	ISO	J:164563
Molecular Function	GO:0098772	molecular function regulator activity	IDA	J:176465
Molecular Function	GO:0003729	mRNA binding	IBA	J:265628
Molecular Function	GO:0003729	mRNA binding	IMP	J:176465
Molecular Function	GO:0003729	mRNA binding	ISO	J:197742
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:206891
Molecular Function	GO:0005515	protein binding	IPI	J:200368
Molecular Function	GO:0005515	protein binding	IPI	J:314085
Molecular Function	GO:0005515	protein binding	IPI	J:188557
Molecular Function	GO:0005515	protein binding	IPI	J:282433
Molecular Function	GO:0005515	protein binding	IPI	J:176465
Molecular Function	GO:0005515	protein binding	IPI	J:176465
Molecular Function	GO:0043422	protein kinase B binding	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	ISO	J:73065
Molecular Function	GO:0050733	RS domain binding	IPI	J:97604
Cellular Component	GO:0071013	catalytic step 2 spliceosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0035145	exon-exon junction complex	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	IBA	J:265628
Cellular Component	GO:0016607	nuclear speck	IDA	J:171647
Cellular Component	GO:0016607	nuclear speck	IDA	J:164388
Cellular Component	GO:0016607	nuclear speck	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:314085
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IPI	J:282433
Cellular Component	GO:0005634	nucleus	ISO	J:197742
Cellular Component	GO:0005634	nucleus	IDA	J:94966
Cellular Component	GO:0005681	spliceosomal complex	IEA	J:60000
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	ISO	J:155856
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	IGI	J:96039
Biological Process	GO:0060048	cardiac muscle contraction	IGI	J:96039
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:282433
Biological Process	GO:0001701	in utero embryonic development	IMP	J:96039
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IMP	J:176465
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IDA	J:176465
Biological Process	GO:0000395	mRNA 5'-splice site recognition	ISO	J:164563
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0000398	mRNA splicing, via spliceosome	IBA	J:265628
Biological Process	GO:0048255	mRNA stabilization	IMP	J:176465
Biological Process	GO:0048255	mRNA stabilization	IDA	J:176465
Biological Process	GO:0051028	mRNA transport	IEA	J:60000
Biological Process	GO:0033120	positive regulation of RNA splicing	ISO	J:155856
Biological Process	GO:0034504	protein localization to nucleus	IDA	J:282433
Biological Process	GO:0110012	protein localization to P-body	IDA	J:282433
Biological Process	GO:0043484	regulation of RNA splicing	IMP	J:314085
Biological Process	GO:0008380	RNA splicing	IGI	J:96039
Biological Process	GO:0008380	RNA splicing	IDA	J:97604
Biological Process	GO:0008380	RNA splicing	IGI	J:96039
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IDA	J:176465
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IMP	J:176465