GO Annotations Graph

• Symbol: Prkce
• Name: protein kinase C, epsilon
• ID: MGI:97599

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	IPI	J:180456
Molecular Function	GO:0003785	actin monomer binding	IDA	J:180491
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	IEA	J:72245
Molecular Function	GO:0004699	calcium-independent protein kinase C activity	IDA	J:74087
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0035276	ethanol binding	IDA	J:152630
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200389
Molecular Function	GO:0005515	protein binding	IPI	J:222149
Molecular Function	GO:0005515	protein binding	IPI	J:180456
Molecular Function	GO:0005515	protein binding	IPI	J:201252
Molecular Function	GO:0005515	protein binding	IPI	J:222156
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004697	protein kinase C activity	ISO	J:164563
Molecular Function	GO:0004697	protein kinase C activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:126967
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0030546	signaling receptor activator activity	IDA	J:126967
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0071944	cell periphery	IDA	J:180462
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:87315
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:131696
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:180462
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:180475
Cellular Component	GO:0016020	membrane	IDA	J:149031
Cellular Component	GO:0005739	mitochondrion	IDA	J:131696
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:87315
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:180462
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0099523	presynaptic cytosol	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0031589	cell-substrate adhesion	IMP	J:106401
Biological Process	GO:0031589	cell-substrate adhesion	IGI	J:106401
Biological Process	GO:0071361	cellular response to ethanol	IGI	J:126967
Biological Process	GO:0071361	cellular response to ethanol	IGI	J:126967
Biological Process	GO:0071456	cellular response to hypoxia	IDA	J:132507
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	ISO	J:155856
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	IDA	J:194901
Biological Process	GO:0007635	chemosensory behavior	TAS	J:79995
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:145117
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:85428
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0030073	insulin secretion	IMP	J:85428
Biological Process	GO:0030073	insulin secretion	IMP	J:85428
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:111048
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:103337
Biological Process	GO:0035641	locomotory exploration behavior	IGI	J:147475
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:103337
Biological Process	GO:0000165	MAPK cascade	IDA	J:131696
Biological Process	GO:0070254	mucus secretion	IMP	J:145117
Biological Process	GO:0070254	mucus secretion	IMP	J:145117
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0051562	negative regulation of mitochondrial calcium ion concentration	ISO	J:155856
Biological Process	GO:0010917	negative regulation of mitochondrial membrane potential	ISO	J:155856
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IMP	J:224799
Biological Process	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IDA	J:180491
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	IMP	J:106401
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	IGI	J:106401
Biological Process	GO:2001031	positive regulation of cellular glucuronidation	ISO	J:164563
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0010763	positive regulation of fibroblast migration	IMP	J:180475
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:103337
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:85428
Biological Process	GO:0050996	positive regulation of lipid catabolic process	IMP	J:154424
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:103337
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:131696
Biological Process	GO:0070257	positive regulation of mucus secretion	IMP	J:145117
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	IMP	J:126967
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:82583
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:154424
Biological Process	GO:0019216	regulation of lipid metabolic process	IMP	J:154424
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IMP	J:77668
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IDA	J:194901
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IMP	J:99016
Biological Process	GO:0043278	response to morphine	IMP	J:137288
Biological Process	GO:0051932	synaptic transmission, GABAergic	IMP	J:126967
Biological Process	GO:0051932	synaptic transmission, GABAergic	IMP	J:126967
Biological Process	GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	IMP	J:111048