GO Annotations Graph

• Symbol: Pdha1
• Name: pyruvate dehydrogenase E1 alpha 1
• ID: MGI:97532

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:263469
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	ISO	J:164563
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	ISO	J:155856
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	IBA	J:265628
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	IMP	J:141289
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	IMP	J:141289
Molecular Function	GO:0004738	pyruvate dehydrogenase activity	IMP	J:74192
Cellular Component	GO:1902494	catalytic complex	IMP	J:74192
Cellular Component	GO:1902494	catalytic complex	IMP	J:123893
Cellular Component	GO:1902494	catalytic complex	IMP	J:94805
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IEA	J:72247
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:242350
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	ISO	J:155856
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	ISO	J:164563
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	ISO	J:164563
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	IBA	J:265628
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	IMP	J:141289
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	IMP	J:141289
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0006006	glucose metabolic process	IEA	J:60000
Biological Process	GO:0006099	tricarboxylic acid cycle	IEA	J:60000