GO Annotations Graph

• Symbol: Pcna
• Name: proliferating cell nuclear antigen
• ID: MGI:97503

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0032139	dinucleotide insertion or deletion binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0070182	DNA polymerase binding	ISO	J:164563
Molecular Function	GO:0030337	DNA polymerase processivity factor activity	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	IPI	J:202812
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0035035	histone acetyltransferase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0032405	MutLalpha complex binding	ISO	J:164563
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:121214
Molecular Function	GO:0005515	protein binding	IPI	J:117431
Molecular Function	GO:0005515	protein binding	IPI	J:248211
Molecular Function	GO:0005515	protein binding	IPI	J:81304
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IPI	J:142927
Cellular Component	GO:0005813	centrosome	ISO	J:204810
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:106653
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:82276
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:82276
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005652	nuclear lamina	IDA	J:81304
Cellular Component	GO:0043596	nuclear replication fork	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:202812
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:162095
Cellular Component	GO:0005634	nucleus	IDA	J:85809
Cellular Component	GO:0005634	nucleus	IDA	J:105978
Cellular Component	GO:0005634	nucleus	IDA	J:142136
Cellular Component	GO:0005634	nucleus	IDA	J:76874
Cellular Component	GO:0005634	nucleus	IDA	J:53290
Cellular Component	GO:0005634	nucleus	IDA	J:88220
Cellular Component	GO:0005634	nucleus	IDA	J:142927
Cellular Component	GO:0005634	nucleus	IDA	J:204433
Cellular Component	GO:0005634	nucleus	IDA	J:195630
Cellular Component	GO:0005634	nucleus	IDA	J:142927
Cellular Component	GO:0005634	nucleus	IDA	J:79935
Cellular Component	GO:0005634	nucleus	IDA	J:78856
Cellular Component	GO:0005634	nucleus	ISS	J:93906
Cellular Component	GO:0043626	PCNA complex	ISO	J:164563
Cellular Component	GO:0043626	PCNA complex	IBA	J:265628
Cellular Component	GO:0070557	PCNA-p21 complex	ISO	J:164563
Cellular Component	GO:0005657	replication fork	ISO	J:113839
Cellular Component	GO:0005657	replication fork	IDA	J:76360
Biological Process	GO:0006287	base-excision repair, gap-filling	IDA	J:91067
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:210952
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006260	DNA replication	IEA	J:60000
Biological Process	GO:0006272	leading strand elongation	IBA	J:265628
Biological Process	GO:0006298	mismatch repair	ISO	J:164563
Biological Process	GO:0006298	mismatch repair	IBA	J:265628
Biological Process	GO:1902990	mitotic telomere maintenance via semi-conservative replication	IGI	J:202812
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:142927
Biological Process	GO:0032077	positive regulation of deoxyribonuclease activity	ISO	J:164563
Biological Process	GO:0045739	positive regulation of DNA repair	ISO	J:164563
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:164563
Biological Process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	ISO	J:164563
Biological Process	GO:0006275	regulation of DNA replication	IEA	J:72247
Biological Process	GO:0031297	replication fork processing	IGI	J:202812
Biological Process	GO:0033993	response to lipid	ISO	J:155856
Biological Process	GO:0019985	translesion synthesis	ISO	J:164563
Biological Process	GO:0019985	translesion synthesis	IBA	J:265628