GO Annotations Graph

• Symbol: Nf2
• Name: neurofibromin 2
• ID: MGI:97307

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IBA	J:265628
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:155856
Molecular Function	GO:0008092	cytoskeletal protein binding	IEA	J:72247
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:213963
Molecular Function	GO:0005515	protein binding	IPI	J:213963
Molecular Function	GO:0005515	protein binding	IPI	J:83082
Molecular Function	GO:0005515	protein binding	IPI	J:86235
Molecular Function	GO:0005515	protein binding	IPI	J:104992
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Cellular Component	GO:0005912	adherens junction	IBA	J:265628
Cellular Component	GO:0005912	adherens junction	IMP	J:83082
Cellular Component	GO:0045177	apical part of cell	IBA	J:265628
Cellular Component	GO:0045177	apical part of cell	IDA	J:199301
Cellular Component	GO:0044297	cell body	IDA	J:218609
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0032154	cleavage furrow	IDA	J:46198
Cellular Component	GO:0030864	cortical actin cytoskeleton	IDA	J:94716
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:31660
Cellular Component	GO:0005737	cytoplasm	IDA	J:31660
Cellular Component	GO:0005737	cytoplasm	IDA	J:31660
Cellular Component	GO:0005737	cytoplasm	IDA	J:91460
Cellular Component	GO:0005856	cytoskeleton	IDA	J:94716
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0030175	filopodium	IBA	J:265628
Cellular Component	GO:0030175	filopodium	IDA	J:46918
Cellular Component	GO:0030027	lamellipodium	IDA	J:46918
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IDA	J:218609
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:91460
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0001726	ruffle	IDA	J:46918
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0007420	brain development	IMP	J:199301
Biological Process	GO:0045216	cell-cell junction organization	IMP	J:83082
Biological Process	GO:0007398	ectoderm development	IMP	J:40596
Biological Process	GO:0021766	hippocampus development	IMP	J:199301
Biological Process	GO:0070306	lens fiber cell differentiation	IMP	J:161172
Biological Process	GO:0000165	MAPK cascade	IMP	J:104992
Biological Process	GO:0001707	mesoderm formation	IMP	J:40596
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:47282
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:0043409	negative regulation of MAPK cascade	IMP	J:104992
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	IMP	J:63264
Biological Process	GO:0006469	negative regulation of protein kinase activity	IDA	J:86235
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:104992
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	IMP	J:63264
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:63264
Biological Process	GO:0033687	osteoblast proliferation	IMP	J:63264
Biological Process	GO:0045597	positive regulation of cell differentiation	IMP	J:199301
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport	IBA	J:265628
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	IBA	J:265628
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:83082
Biological Process	GO:0008360	regulation of cell shape	IBA	J:265628
Biological Process	GO:0014013	regulation of gliogenesis	IBA	J:265628
Biological Process	GO:0014013	regulation of gliogenesis	IMP	J:218609
Biological Process	GO:0035330	regulation of hippo signaling	ISO	J:164563
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	IMP	J:199301
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:218609
Biological Process	GO:1902115	regulation of organelle assembly	IBA	J:265628
Biological Process	GO:1900180	regulation of protein localization to nucleus	IMP	J:199301
Biological Process	GO:0031647	regulation of protein stability	IMP	J:199301
Biological Process	GO:0072091	regulation of stem cell proliferation	IGI	J:218609
Biological Process	GO:0072091	regulation of stem cell proliferation	IMP	J:218609
Biological Process	GO:0014010	Schwann cell proliferation	ISO	J:164563
Biological Process	GO:0014010	Schwann cell proliferation	IMP	J:63264