GO Annotations Graph

• Symbol: Lyn
• Name: LYN proto-oncogene, Src family tyrosine kinase
• ID: MGI:96892

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0004857	enzyme inhibitor activity	ISO	J:164563
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0005128	erythropoietin receptor binding	TAS	J:116375
Molecular Function	GO:0043015	gamma-tubulin binding	ISO	J:155856
Molecular Function	GO:0043208	glycosphingolipid binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IMP	J:244275
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:200363
Molecular Function	GO:0005515	protein binding	IPI	J:146296
Molecular Function	GO:0005515	protein binding	IPI	J:116375
Molecular Function	GO:0005515	protein binding	IPI	J:195394
Molecular Function	GO:0005515	protein binding	IPI	J:232061
Molecular Function	GO:0005515	protein binding	IPI	J:124931
Molecular Function	GO:0005515	protein binding	IPI	J:244275
Molecular Function	GO:0005515	protein binding	IPI	J:82731
Molecular Function	GO:0005515	protein binding	IPI	J:78670
Molecular Function	GO:0005515	protein binding	IPI	J:129312
Molecular Function	GO:0005515	protein binding	IPI	J:194234
Molecular Function	GO:0004672	protein kinase activity	IDA	J:37676
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:72269
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:82731
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:266150
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:266145
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-983702
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:62510
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:29834
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:148303
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:148303
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:148303
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:148303
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	IPI	J:148303
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0005912	adherens junction	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:116375
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1168927
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1433273
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006326
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006327
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006329
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012652
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012653
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012656
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027266
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027429
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027436
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029146
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029147
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029152
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029162
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9030346
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9030353
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9032476
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9607032
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674900
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674908
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674921
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674931
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674959
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674973
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676072
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705471
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707972
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707979
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-983702
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0034666	integrin alpha2-beta1 complex	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	IDA	J:74532
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0030061	mitochondrial crista	ISO	J:155856
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:155856
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:116375
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:148303
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0099091	postsynaptic specialization, intracellular component	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:82731
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0001782	B cell homeostasis	IMP	J:42037
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:29834
Biological Process	GO:0050853	B cell receptor signaling pathway	IGI	J:194234
Biological Process	GO:0038159	C-X-C chemokine receptor CXCR4 signaling pathway	ISO	J:164563
Biological Process	GO:0071300	cellular response to retinoic acid	ISO	J:164563
Biological Process	GO:0097028	dendritic cell differentiation	IMP	J:107272
Biological Process	GO:0097028	dendritic cell differentiation	IBA	J:265628
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IBA	J:265628
Biological Process	GO:0030222	eosinophil differentiation	ISO	J:164563
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:116375
Biological Process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	IMP	J:119693
Biological Process	GO:0002431	Fc receptor mediated stimulatory signaling pathway	IMP	J:119693
Biological Process	GO:0002431	Fc receptor mediated stimulatory signaling pathway	IBA	J:265628
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ISO	J:164563
Biological Process	GO:0042541	hemoglobin biosynthetic process	TAS	J:116375
Biological Process	GO:0030097	hemopoiesis	IMP	J:72269
Biological Process	GO:0002553	histamine secretion by mast cell	ISO	J:155856
Biological Process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	IMP	J:42037
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0038043	interleukin-5-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:37676
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:161005
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:42037
Biological Process	GO:0030889	negative regulation of B cell proliferation	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:90545
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:113243
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:90545
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:87475
Biological Process	GO:1902532	negative regulation of intracellular signal transduction	IMP	J:87475
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:42037
Biological Process	GO:0070667	negative regulation of mast cell proliferation	IMP	J:87475
Biological Process	GO:0070667	negative regulation of mast cell proliferation	IBA	J:265628
Biological Process	GO:0002762	negative regulation of myeloid leukocyte differentiation	IMP	J:72269
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:87475
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	IMP	J:161005
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	IMP	J:161005
Biological Process	GO:0031175	neuron projection development	IBA	J:265628
Biological Process	GO:0031175	neuron projection development	IMP	J:146203
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:72269
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:82731
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:244275
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:129312
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:29834
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0002576	platelet degranulation	IMP	J:178438
Biological Process	GO:0002576	platelet degranulation	IBA	J:265628
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:70417
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:116375
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:70417
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	IMP	J:113243
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	IBA	J:265628
Biological Process	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO	J:155856
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0070668	positive regulation of mast cell proliferation	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	ISO	J:155856
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IMP	J:178287
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:116375
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:72269
Biological Process	GO:0046777	protein autophosphorylation	TAS	J:78594
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:29834
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:37676
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0002902	regulation of B cell apoptotic process	IMP	J:35280
Biological Process	GO:0002902	regulation of B cell apoptotic process	IBA	J:265628
Biological Process	GO:0050855	regulation of B cell receptor signaling pathway	IMP	J:72269
Biological Process	GO:0050855	regulation of B cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0001817	regulation of cytokine production	IMP	J:119693
Biological Process	GO:0001817	regulation of cytokine production	IMP	J:161005
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	IMP	J:42037
Biological Process	GO:0045646	regulation of erythrocyte differentiation	IMP	J:178285
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:107272
Biological Process	GO:0033003	regulation of mast cell activation	IMP	J:119693
Biological Process	GO:0043304	regulation of mast cell degranulation	IMP	J:119693
Biological Process	GO:0043304	regulation of mast cell degranulation	IBA	J:265628
Biological Process	GO:0090025	regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0090330	regulation of platelet aggregation	IMP	J:178438
Biological Process	GO:0090330	regulation of platelet aggregation	IBA	J:265628
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IGI	J:194234
Biological Process	GO:0009725	response to hormone	IDA	J:116375
Biological Process	GO:0007165	signal transduction	TAS	J:116375
Biological Process	GO:0002513	tolerance induction to self antigen	IMP	J:42037
Biological Process	GO:0002513	tolerance induction to self antigen	IBA	J:265628
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IMP	J:244275
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628