GO Annotations Graph

• Symbol: Lhx2
• Name: LIM homeobox protein 2
• ID: MGI:96785

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:145977
Molecular Function	GO:0003682	chromatin binding	IDA	J:202029
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:239218
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:239218
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:227000
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:172915
Molecular Function	GO:0005515	protein binding	IPI	J:237908
Molecular Function	GO:0005515	protein binding	IPI	J:239195
Molecular Function	GO:0005515	protein binding	IPI	J:177242
Molecular Function	GO:0005515	protein binding	IPI	J:49807
Molecular Function	GO:0005515	protein binding	IPI	J:56497
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:237908
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:239218
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:90847
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:90847
Molecular Function	GO:0008134	transcription factor binding	IPI	J:129101
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:57340
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9011075
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9011082
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9011146
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9753028
Cellular Component	GO:0005634	nucleus	IMP	J:237908
Cellular Component	GO:0005634	nucleus	IMP	J:227000
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:130846
Cellular Component	GO:0005634	nucleus	IDA	J:202029
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:73082
Biological Process	GO:0048675	axon extension	IDA	J:179784
Biological Process	GO:0007411	axon guidance	IMP	J:183861
Biological Process	GO:0007411	axon guidance	IMP	J:122567
Biological Process	GO:0007420	brain development	IMP	J:86254
Biological Process	GO:0007420	brain development	IMP	J:91847
Biological Process	GO:0021987	cerebral cortex development	IMP	J:237908
Biological Process	GO:0021987	cerebral cortex development	IMP	J:227000
Biological Process	GO:0021987	cerebral cortex development	IMP	J:154611
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:67304
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:86254
Biological Process	GO:0001942	hair follicle development	IMP	J:202029
Biological Process	GO:0045199	maintenance of epithelial cell apical/basal polarity	IMP	J:202029
Biological Process	GO:0007498	mesoderm development	IMP	J:64676
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	IMP	J:237908
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:227000
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:237908
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IGI	J:49807
Biological Process	GO:0007399	nervous system development	IMP	J:64676
Biological Process	GO:0001843	neural tube closure	IMP	J:73082
Biological Process	GO:0022008	neurogenesis	IDA	J:133461
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0030182	neuron differentiation	IMP	J:90847
Biological Process	GO:0021772	olfactory bulb development	IMP	J:154611
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:172915
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:219181
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	IMP	J:227000
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:227000
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:239218
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:145977
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:145977
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:202029
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:56497
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060041	retina development in camera-type eye	IGI	J:145977
Biological Process	GO:0021537	telencephalon development	IMP	J:67304
Biological Process	GO:0021537	telencephalon development	IMP	J:122567
Biological Process	GO:0021537	telencephalon development	IMP	J:154611
Biological Process	GO:0021537	telencephalon development	IMP	J:73082
Biological Process	GO:0021978	telencephalon regionalization	IGI	J:73082
Biological Process	GO:0021978	telencephalon regionalization	IGI	J:73082
Biological Process	GO:0021978	telencephalon regionalization	IMP	J:73082