GO Annotations Graph

• Symbol: Lef1
• Name: lymphoid enhancer binding factor 1
• ID: MGI:96770

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070016	armadillo repeat domain binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:89066
Molecular Function	GO:0003682	chromatin binding	IDA	J:119030
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:89066
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:114817
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:94049
Molecular Function	GO:0003677	DNA binding	IDA	J:115171
Molecular Function	GO:0003677	DNA binding	IDA	J:112463
Molecular Function	GO:0008301	DNA binding, bending	EXP	J:326237
Molecular Function	GO:0008301	DNA binding, bending	IDA	J:115171
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:210934
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:112463
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:94049
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:73689
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IGI	J:96431
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IGI	J:96431
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IGI	J:96431
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	J:270267
Molecular Function	GO:0045295	gamma-catenin binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	EXP	J:326237
Molecular Function	GO:0005515	protein binding	IPI	J:168158
Molecular Function	GO:0005515	protein binding	IPI	J:200499
Molecular Function	GO:0005515	protein binding	IPI	J:173032
Molecular Function	GO:0005515	protein binding	IPI	J:116387
Molecular Function	GO:0005515	protein binding	IPI	J:153213
Molecular Function	GO:0005515	protein binding	IPI	J:96431
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0005515	protein binding	IPI	J:73179
Molecular Function	GO:0005515	protein binding	IPI	J:270267
Molecular Function	GO:0005515	protein binding	IPI	J:73689
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:165064
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:210934
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:140203
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:94049
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:205649
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:203028
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:24350
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:82780
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:142037
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IPI	J:82780
Molecular Function	GO:0008134	transcription factor binding	IPI	J:82780
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Cellular Component	GO:1990907	beta-catenin-TCF complex	IDA	J:165064
Cellular Component	GO:1990907	beta-catenin-TCF complex	ISO	J:164563
Cellular Component	GO:1990907	beta-catenin-TCF complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:210448
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:86666
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9754284
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9793864
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9794042
Cellular Component	GO:0005634	nucleus	IDA	J:165064
Cellular Component	GO:0005634	nucleus	IDA	J:164710
Cellular Component	GO:0005634	nucleus	IDA	J:210448
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:112463
Cellular Component	GO:0005634	nucleus	IPI	J:270267
Cellular Component	GO:0005634	nucleus	IDA	J:270267
Cellular Component	GO:0005634	nucleus	IDA	J:86666
Cellular Component	GO:0005634	nucleus	IDA	J:205544
Cellular Component	GO:0005634	nucleus	IDA	J:171374
Cellular Component	GO:0005634	nucleus	IDA	J:205544
Cellular Component	GO:0005634	nucleus	IDA	J:86666
Cellular Component	GO:0005634	nucleus	IDA	J:82780
Cellular Component	GO:0005634	nucleus	IDA	J:134051
Cellular Component	GO:0005634	nucleus	IDA	J:205544
Cellular Component	GO:0005634	nucleus	IDA	J:24350
Cellular Component	GO:0005634	nucleus	IDA	J:55937
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IPI	J:314560
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:270267
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:73689
Biological Process	GO:0046632	alpha-beta T cell differentiation	IGI	J:110481
Biological Process	GO:0060033	anatomical structure regression	IMP	J:101493
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	IMP	J:96501
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	IMP	J:96501
Biological Process	GO:0042100	B cell proliferation	IMP	J:63678
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:50462
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:144980
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:112463
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:63678
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:110699
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:50462
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:124680
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0048468	cell development	IGI	J:96431
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0071353	cellular response to interleukin-4	ISO	J:164563
Biological Process	GO:0060710	chorio-allantoic fusion	IGI	J:54101
Biological Process	GO:0021542	dentate gyrus development	IMP	J:59284
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:54101
Biological Process	GO:1904019	epithelial cell apoptotic process	IMP	J:96501
Biological Process	GO:1904019	epithelial cell apoptotic process	IMP	J:96501
Biological Process	GO:0001837	epithelial to mesenchymal transition	IMP	J:87103
Biological Process	GO:0060325	face morphogenesis	IGI	J:124680
Biological Process	GO:0021873	forebrain neuroblast division	IGI	J:87386
Biological Process	GO:0021861	forebrain radial glial cell differentiation	IGI	J:87386
Biological Process	GO:0021943	formation of radial glial scaffolds	IGI	J:87386
Biological Process	GO:0021766	hippocampus development	IMP	J:59284
Biological Process	GO:0030879	mammary gland development	IMP	J:110699
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0071866	negative regulation of apoptotic process in bone marrow cell	ISO	J:164563
Biological Process	GO:0043392	negative regulation of DNA binding	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:82780
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:82780
Biological Process	GO:0032696	negative regulation of interleukin-13 production	ISO	J:164563
Biological Process	GO:0032713	negative regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0032714	negative regulation of interleukin-5 production	ISO	J:164563
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	IDA	J:112463
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:114817
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:142037
Biological Process	GO:0030223	neutrophil differentiation	ISO	J:164563
Biological Process	GO:0071895	odontoblast differentiation	ISO	J:155856
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:96501
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:80990
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:124680
Biological Process	GO:0048341	paraxial mesoderm formation	IGI	J:54101
Biological Process	GO:0043923	positive regulation by host of viral transcription	ISO	J:164563
Biological Process	GO:0090068	positive regulation of cell cycle process	ISO	J:164563
Biological Process	GO:0045597	positive regulation of cell differentiation	NAS	J:320407
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	ISO	J:164563
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	IMP	J:270267
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:59284
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:59284
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:270267
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:63678
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IMP	J:196163
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:165064
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:210934
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:112463
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:89274
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:89274
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:94049
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:89274
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:119729
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:82999
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IMP	J:270267
Biological Process	GO:0071168	protein localization to chromatin	ISO	J:164563
Biological Process	GO:0022407	regulation of cell-cell adhesion	IMP	J:144980
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:196163
Biological Process	GO:0050767	regulation of neurogenesis	NAS	J:320138
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:73689
Biological Process	GO:0030111	regulation of Wnt signaling pathway	IGI	J:54101
Biological Process	GO:0062009	secondary palate development	IMP	J:87103
Biological Process	GO:0050909	sensory perception of taste	IMP	J:119729
Biological Process	GO:0001756	somitogenesis	IGI	J:54101
Biological Process	GO:0001756	somitogenesis	IMP	J:94049
Biological Process	GO:0002040	sprouting angiogenesis	IMP	J:144980
Biological Process	GO:0033153	T cell receptor V(D)J recombination	IGI	J:110481
Biological Process	GO:0045063	T-helper 1 cell differentiation	IDA	J:164710
Biological Process	GO:0043586	tongue development	IMP	J:119729
Biological Process	GO:0061153	trachea gland development	IMP	J:57699
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:119729
Biological Process	GO:0001944	vasculature development	IMP	J:101493
Biological Process	GO:0001944	vasculature development	IMP	J:101493
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:72247