GO Annotations Graph

• Symbol: Krt1
• Name: keratin 1
• ID: MGI:96698

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030246	carbohydrate binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:76311
Molecular Function	GO:0005515	protein binding	IPI	J:322687
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0030280	structural constituent of skin epidermis	ISO	J:164563
Molecular Function	GO:0030280	structural constituent of skin epidermis	IBA	J:265628
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:213088
Cellular Component	GO:0001533	cornified envelope	ISO	J:164563
Cellular Component	GO:0001533	cornified envelope	IDA	J:230728
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005882	intermediate filament	IEA	J:60000
Cellular Component	GO:0045095	keratin filament	ISO	J:164563
Cellular Component	GO:0045095	keratin filament	IBA	J:265628
Cellular Component	GO:0045095	keratin filament	IDA	J:2991
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0001867	complement activation, lectin pathway	ISO	J:164563
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:200244
Biological Process	GO:0045109	intermediate filament organization	IBA	J:265628
Biological Process	GO:0031424	keratinization	IBA	J:265628
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:200244
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:200244
Biological Process	GO:0018149	peptide cross-linking	ISO	J:164563
Biological Process	GO:0051290	protein heterotetramerization	ISO	J:164563