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GO Annotations Graph
Symbol
Name
ID
Irf1
interferon regulatory factor 1
MGI:96590

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003677DNA bindingIDAJ:86244
Molecular FunctionGO:0005515protein bindingIPIJ:177242
Molecular FunctionGO:0005515protein bindingIPIJ:191206
Molecular FunctionGO:0005515protein bindingIPIJ:115304
Molecular FunctionGO:0005515protein bindingIPIJ:176666
Molecular FunctionGO:0000975regulatory region DNA bindingIEAJ:72247
Molecular FunctionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISOJ:164563
Molecular FunctionGO:0043565sequence-specific DNA bindingIDAJ:121092
Molecular FunctionGO:0043565sequence-specific DNA bindingISOJ:155856
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingIDAJ:121092
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingISOJ:155856
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingIDAJ:86244
Molecular FunctionGO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingISOJ:164563
Cellular ComponentGO:0005737cytoplasmIDAJ:115304
Cellular ComponentGO:0000790nuclear chromatinISOJ:164563
Cellular ComponentGO:0005634nucleusIDAJ:115304
Cellular ComponentGO:0005634nucleusICJ:86244
Cellular ComponentGO:0005634nucleusISOJ:155856
Biological ProcessGO:0006915apoptotic processISOJ:164563
Biological ProcessGO:0043374CD8-positive, alpha-beta T cell differentiationIMPJ:69487
Biological ProcessGO:0007050cell cycle arrestISOJ:164563
Biological ProcessGO:0035458cellular response to interferon-betaISOJ:164563
Biological ProcessGO:0071347cellular response to interleukin-1ISOJ:155856
Biological ProcessGO:0071375cellular response to peptide hormone stimulusISOJ:155856
Biological ProcessGO:0071356cellular response to tumor necrosis factorISOJ:155856
Biological ProcessGO:0051607defense response to virusISOJ:164563
Biological ProcessGO:0051607defense response to virusIMPJ:167950
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingISOJ:155856
Biological ProcessGO:0002376immune system processIEAJ:60000
Biological ProcessGO:0045087innate immune responseIEAJ:60000
Biological ProcessGO:0060333interferon-gamma-mediated signaling pathwayIMPJ:183131
Biological ProcessGO:0008285negative regulation of cell proliferationIEAJ:72247
Biological ProcessGO:0045590negative regulation of regulatory T cell differentiationIMPJ:137875
Biological ProcessGO:0045629negative regulation of T-helper 2 cell differentiationTASJ:183979
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedIDAJ:137875
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0042512negative regulation of tyrosine phosphorylation of Stat1 proteinISOJ:155856
Biological ProcessGO:0010942positive regulation of cell deathISOJ:155856
Biological ProcessGO:0032728positive regulation of interferon-beta productionISOJ:164563
Biological ProcessGO:0045084positive regulation of interleukin-12 biosynthetic processIDAJ:86244
Biological ProcessGO:0045084positive regulation of interleukin-12 biosynthetic processIMPJ:86244
Biological ProcessGO:0032825positive regulation of natural killer cell differentiationTASJ:183979
Biological ProcessGO:0045627positive regulation of T-helper 1 cell differentiationTASJ:183979
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:121092
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:155856
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIMPJ:160488
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:86244
Biological ProcessGO:0032481positive regulation of type I interferon productionIMPJ:115304
Biological ProcessGO:0002819regulation of adaptive immune responseTASJ:183131
Biological ProcessGO:2000564regulation of CD8-positive, alpha-beta T cell proliferationIMPJ:183131
Biological ProcessGO:0010468regulation of gene expressionIMPJ:69487
Biological ProcessGO:0050776regulation of immune responseIEAJ:72247
Biological ProcessGO:0045088regulation of innate immune responseTASJ:183131
Biological ProcessGO:0034124regulation of MyD88-dependent toll-like receptor signaling pathwayIMPJ:115304
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:72247
Biological ProcessGO:0060416response to growth hormoneISOJ:155856
Biological ProcessGO:0006351transcription, DNA-templatedIEAJ:60000


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory