GO Annotations Graph

• Symbol: Irf1
• Name: interferon regulatory factor 1
• ID: MGI:96590

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:86244
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:121092
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:86244
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:236523
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IMP	J:279203
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:231714
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:176666
Molecular Function	GO:0005515	protein binding	IPI	J:177242
Molecular Function	GO:0005515	protein binding	IPI	J:115304
Molecular Function	GO:0005515	protein binding	IPI	J:191206
Molecular Function	GO:0005515	protein binding	IPI	J:191206
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:121092
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:115304
Cellular Component	GO:0005634	nucleus	IDA	J:115304
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IMP	J:279203
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IC	J:86244
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0043374	CD8-positive, alpha-beta T cell differentiation	IMP	J:69487
Biological Process	GO:0043374	CD8-positive, alpha-beta T cell differentiation	IMP	J:69487
Biological Process	GO:0043374	CD8-positive, alpha-beta T cell differentiation	IMP	J:69487
Biological Process	GO:0035458	cellular response to interferon-beta	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:155856
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	ISO	J:155856
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:155856
Biological Process	GO:0051607	defense response to virus	IMP	J:167950
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:279203
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0002376	immune system process	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	IEA	J:72247
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:137875
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	IMP	J:137875
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	TAS	J:183979
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:160488
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:86244
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:86244
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:86244
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	TAS	J:183979
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	TAS	J:183979
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:279203
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:121092
Biological Process	GO:0032481	positive regulation of type I interferon production	IMP	J:115304
Biological Process	GO:0002819	regulation of adaptive immune response	TAS	J:183131
Biological Process	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	IMP	J:183131
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:69487
Biological Process	GO:0050776	regulation of immune response	IEA	J:72247
Biological Process	GO:0045088	regulation of innate immune response	TAS	J:183131
Biological Process	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway	IMP	J:115304
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060416	response to growth hormone	ISO	J:155856
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:121092
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	IMP	J:183131