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GO Annotations Graph
Symbol
Name
ID
Il4
interleukin 4
MGI:96556

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005125cytokine activityIDAJ:1013
Molecular FunctionGO:0005125cytokine activityIDAJ:64603
Molecular FunctionGO:0005125cytokine activityIDAJ:76115
Molecular FunctionGO:0005125cytokine activityIDAJ:112035
Molecular FunctionGO:0005125cytokine activityIDAJ:88533
Molecular FunctionGO:0005125cytokine activityIDAJ:98326
Molecular FunctionGO:0005126cytokine receptor bindingIEAJ:72247
Molecular FunctionGO:0008083growth factor activityIEAJ:72247
Molecular FunctionGO:0008083growth factor activityIEAJ:60000
Molecular FunctionGO:0005136interleukin-4 receptor bindingIEAJ:72247
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:165919
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:175944
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:160369
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:168252
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:151963
Cellular ComponentGO:0005576extracellular regionIEAJ:72247
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005615extracellular spaceIDAJ:143981
Cellular ComponentGO:0005615extracellular spaceIDAJ:147177
Cellular ComponentGO:0005615extracellular spaceIDAJ:140498
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0005615extracellular spaceIDAJ:116306
Cellular ComponentGO:0005615extracellular spaceIDAJ:172134
Cellular ComponentGO:0005615extracellular spaceIDAJ:65439
Cellular ComponentGO:0005615extracellular spaceIDAJ:75400
Cellular ComponentGO:0005615extracellular spaceIDAJ:91286
Cellular ComponentGO:0005615extracellular spaceIDAJ:117165
Biological ProcessGO:0042113B cell activationIDAJ:100706
Biological ProcessGO:0042113B cell activationIDAJ:62630
Biological ProcessGO:0031296B cell costimulationIDAJ:141184
Biological ProcessGO:0008203cholesterol metabolic processIMPJ:76258
Biological ProcessGO:0042832defense response to protozoanIMPJ:20463
Biological ProcessGO:0097028dendritic cell differentiationISOJ:164563
Biological ProcessGO:0097192extrinsic apoptotic signaling pathway in absence of ligandIDAJ:78230
Biological ProcessGO:0006955immune responseIEAJ:72247
Biological ProcessGO:0002227innate immune response in mucosaIDAJ:172916
Biological ProcessGO:0001774microglial cell activationISOJ:155856
Biological ProcessGO:0043011myeloid dendritic cell differentiationISOJ:164563
Biological ProcessGO:0002674negative regulation of acute inflammatory responseISOJ:155856
Biological ProcessGO:0002677negative regulation of chronic inflammatory responseISOJ:155856
Biological ProcessGO:1903660negative regulation of complement-dependent cytotoxicityISOJ:164563
Biological ProcessGO:2000352negative regulation of endothelial cell apoptotic processISOJ:164563
Biological ProcessGO:0010633negative regulation of epithelial cell migrationISOJ:164563
Biological ProcessGO:2001237negative regulation of extrinsic apoptotic signaling pathwayIDAJ:56164
Biological ProcessGO:0043031negative regulation of macrophage activationISOJ:155856
Biological ProcessGO:0045019negative regulation of nitric oxide biosynthetic processISOJ:155856
Biological ProcessGO:0045671negative regulation of osteoclast differentiationIDAJ:85571
Biological ProcessGO:0050868negative regulation of T cell activationIDAJ:143168
Biological ProcessGO:2000320negative regulation of T-helper 17 cell differentiationIDAJ:141227
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0070351negative regulation of white fat cell proliferationIDAJ:208361
Biological ProcessGO:0042104positive regulation of activated T cell proliferationIDAJ:112035
Biological ProcessGO:0042104positive regulation of activated T cell proliferationIDAJ:98326
Biological ProcessGO:0050871positive regulation of B cell activationIDAJ:30239
Biological ProcessGO:0030890positive regulation of B cell proliferationIDAJ:106733
Biological ProcessGO:0030890positive regulation of B cell proliferationIDAJ:64603
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:155856
Biological ProcessGO:0045080positive regulation of chemokine biosynthetic processIDAJ:38368
Biological ProcessGO:0002230positive regulation of defense response to virus by hostISOJ:155856
Biological ProcessGO:2000424positive regulation of eosinophil chemotaxisISOJ:155856
Biological ProcessGO:0002639positive regulation of immunoglobulin productionIMPJ:100883
Biological ProcessGO:0002639positive regulation of immunoglobulin productionIGIJ:100883
Biological ProcessGO:0032733positive regulation of interleukin-10 productionISOJ:155856
Biological ProcessGO:0032736positive regulation of interleukin-13 productionISOJ:164563
Biological ProcessGO:0048295positive regulation of isotype switching to IgE isotypesIDAJ:88910
Biological ProcessGO:0048304positive regulation of isotype switching to IgG isotypesIDAJ:84929
Biological ProcessGO:0048304positive regulation of isotype switching to IgG isotypesIDAJ:88910
Biological ProcessGO:0043306positive regulation of mast cell degranulationIGIJ:100883
Biological ProcessGO:0043306positive regulation of mast cell degranulationIMPJ:100883
Biological ProcessGO:0045348positive regulation of MHC class II biosynthetic processIDAJ:88533
Biological ProcessGO:0045348positive regulation of MHC class II biosynthetic processIDAJ:76115
Biological ProcessGO:0071677positive regulation of mononuclear cell migrationISOJ:155856
Biological ProcessGO:1901741positive regulation of myoblast fusionIDAJ:107688
Biological ProcessGO:1901741positive regulation of myoblast fusionIMPJ:107688
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDAJ:19201
Biological ProcessGO:0001934positive regulation of protein phosphorylationIDAJ:78230
Biological ProcessGO:1903428positive regulation of reactive oxygen species biosynthetic processISOJ:155856
Biological ProcessGO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDAJ:26926
Biological ProcessGO:0045582positive regulation of T cell differentiationISOJ:164563
Biological ProcessGO:0042102positive regulation of T cell proliferationIDAJ:143168
Biological ProcessGO:0042102positive regulation of T cell proliferationIDAJ:1013
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:18351
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIGIJ:39815
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:90824
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:143168
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:125784
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:1013
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:26926
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedISOJ:155856
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:175335
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDAJ:98326
Biological ProcessGO:0050776regulation of immune responseIDAJ:84929
Biological ProcessGO:0050727regulation of inflammatory responseISOJ:155856
Biological ProcessGO:0010155regulation of proton transportISOJ:155856
Biological ProcessGO:0002296T-helper 1 cell lineage commitmentIGIJ:165738
Biological ProcessGO:0035745T-helper 2 cell cytokine productionISOJ:164563
Biological ProcessGO:0045064T-helper 2 cell differentiationIDAJ:165738


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory