GO Annotations Graph

• Symbol: Il1r1
• Name: interleukin 1 receptor, type I
• ID: MGI:96545

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0019966	interleukin-1 binding	IBA	J:265628
Molecular Function	GO:0019966	interleukin-1 binding	IPI	J:193599
Molecular Function	GO:0004908	interleukin-1 receptor activity	ISO	J:164563
Molecular Function	GO:0004908	interleukin-1 receptor activity	IDA	J:64697
Molecular Function	GO:0004908	interleukin-1 receptor activity	IDA	J:76518
Molecular Function	GO:0004908	interleukin-1 receptor activity	IMP	J:193599
Molecular Function	GO:0004909	interleukin-1, type I, activating receptor activity	IEA	J:72247
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0050135	NAD(P)+ nucleosidase activity	IEA	J:72245
Molecular Function	GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	IEA	J:72245
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	IPI	J:169801
Molecular Function	GO:0005515	protein binding	IPI	J:64697
Molecular Function	GO:0005515	protein binding	IPI	J:107309
Molecular Function	GO:0005515	protein binding	IPI	J:175135
Molecular Function	GO:0005515	protein binding	IPI	J:93342
Molecular Function	GO:0005515	protein binding	IPI	J:93342
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:154864
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:190936
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:93342
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:76518
Biological Process	GO:0010286	heat acclimation	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IDA	J:64697
Biological Process	GO:2000661	positive regulation of interleukin-1-mediated signaling pathway	IMP	J:193599
Biological Process	GO:2001224	positive regulation of neuron migration	ISO	J:155856
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	IMP	J:193599
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0050727	regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:181354
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0009314	response to radiation	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247