GO Annotations Graph

• Symbol: Il1b
• Name: interleukin 1 beta
• ID: MGI:96543

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:93342
Molecular Function	GO:0005125	cytokine activity	ISO	J:73065
Molecular Function	GO:0005125	cytokine activity	IDA	J:85159
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005149	interleukin-1 receptor binding	IEA	J:72247
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:213232
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:67213
Cellular Component	GO:0005615	extracellular space	IDA	J:99000
Cellular Component	GO:0005615	extracellular space	IDA	J:295244
Cellular Component	GO:0005615	extracellular space	IDA	J:208236
Cellular Component	GO:0005615	extracellular space	IDA	J:110582
Cellular Component	GO:0005615	extracellular space	IDA	J:66835
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0030141	secretory granule	IDA	J:110582
Cellular Component	GO:0031982	vesicle	IDA	J:99000
Biological Process	GO:0048143	astrocyte activation	IDA	J:259461
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:269278
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0071310	cellular response to organic substance	ISO	J:145965
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:145965
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:115619
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:115619
Biological Process	GO:0001660	fever generation	IEA	J:60000
Biological Process	GO:0030213	hyaluronan biosynthetic process	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0032635	interleukin-6 production	IDA	J:98417
Biological Process	GO:0032635	interleukin-6 production	IDA	J:93342
Biological Process	GO:0007254	JNK cascade	IDA	J:102721
Biological Process	GO:0007254	JNK cascade	IGI	J:102721
Biological Process	GO:0050900	leukocyte migration	IDA	J:88722
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:98417
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0070487	monocyte aggregation	ISO	J:164563
Biological Process	GO:0070164	negative regulation of adiponectin secretion	IDA	J:143678
Biological Process	GO:2000173	negative regulation of branching morphogenesis of a nerve	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:1903597	negative regulation of gap junction assembly	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010829	negative regulation of glucose transmembrane transport	IDA	J:143678
Biological Process	GO:0014050	negative regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IDA	J:143678
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0045833	negative regulation of lipid metabolic process	IDA	J:143678
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IDA	J:143678
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0050768	negative regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0050805	negative regulation of synaptic transmission	IMP	J:241477
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	IDA	J:85159
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:82394
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	ISO	J:155856
Biological Process	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IDA	J:85159
Biological Process	GO:0045917	positive regulation of complement activation	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0031622	positive regulation of fever generation	IDA	J:155398
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:151963
Biological Process	GO:0045687	positive regulation of glial cell differentiation	ISO	J:155856
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:164563
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	ISO	J:164563
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	ISO	J:155856
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IBA	J:265628
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:161934
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:152781
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:73065
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:85159
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:93342
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:241477
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:102721
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:102721
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:155856
Biological Process	GO:0050996	positive regulation of lipid catabolic process	IDA	J:143678
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	ISO	J:164563
Biological Process	GO:0035505	positive regulation of myosin light chain kinase activity	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	IGI	J:241477
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:164563
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	IDA	J:155398
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:1902680	positive regulation of RNA biosynthetic process	ISO	J:164563
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:152781
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IMP	J:82394
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0050691	regulation of defense response to virus by host	IDA	J:213232
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0050767	regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IDA	J:228116
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IBA	J:265628
Biological Process	GO:0033198	response to ATP	IDA	J:122152
Biological Process	GO:0033198	response to ATP	IMP	J:136350
Biological Process	GO:0033198	response to ATP	IDA	J:99000
Biological Process	GO:0033198	response to ATP	IDA	J:136350
Biological Process	GO:0009743	response to carbohydrate	IDA	J:122152
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:110582
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:136350
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:136350
Biological Process	GO:0030730	sequestering of triglyceride	ISO	J:164563
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0010573	vascular endothelial growth factor production	ISO	J:164563