GO Annotations Graph

• Symbol: Ighm
• Name: immunoglobulin heavy constant mu
• ID: MGI:96448

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003823	antigen binding	IDA	J:84929
Molecular Function	GO:0003823	antigen binding	IDA	J:31133
Molecular Function	GO:0003823	antigen binding	IDA	J:88910
Molecular Function	GO:0003823	antigen binding	IDA	J:64281
Molecular Function	GO:0003823	antigen binding	IDA	J:14194
Molecular Function	GO:0003823	antigen binding	IDA	J:19437
Molecular Function	GO:0003823	antigen binding	IDA	J:60916
Molecular Function	GO:0003823	antigen binding	IDA	J:19552
Molecular Function	GO:0003823	antigen binding	IDA	J:30239
Molecular Function	GO:0042802	identical protein binding	IPI	J:220497
Molecular Function	GO:0034987	immunoglobulin receptor binding	ISO	J:164563
Molecular Function	GO:0034987	immunoglobulin receptor binding	IPI	J:221557
Molecular Function	GO:0042834	peptidoglycan binding	ISO	J:164563
Molecular Function	GO:0031210	phosphatidylcholine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:94881
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:94881
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:29796
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:31133
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:60916
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:42368
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:94881
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:87927
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:29796
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:31951
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:29796
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:64281
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:84929
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:88708
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:49405
Cellular Component	GO:0009986	cell surface	IDA	J:218542
Cellular Component	GO:0005737	cytoplasm	IDA	J:252910
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29797
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:88708
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:155898
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:33466
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:64603
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:94881
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:60916
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:99189
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29797
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:87927
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:42368
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:53400
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29796
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:98417
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:30239
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29796
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29797
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29796
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84929
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:19437
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31951
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:64281
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:127719
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:221557
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:123631
Cellular Component	GO:0005615	extracellular space	IDA	J:49405
Cellular Component	GO:0071757	hexameric IgM immunoglobulin complex	ISO	J:164563
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:19437
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:64281
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:84929
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:31133
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:88910
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:85084
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:60916
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:89322
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:14194
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:19552
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:65439
Cellular Component	GO:0042571	immunoglobulin complex, circulating	IDA	J:30239
Cellular Component	GO:0016020	membrane	IDA	J:49405
Cellular Component	GO:0071756	pentameric IgM immunoglobulin complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:94881
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-983702
Biological Process	GO:0002250	adaptive immune response	ISO	J:164563
Biological Process	GO:0019731	antibacterial humoral response	ISO	J:164563
Biological Process	GO:0019882	antigen processing and presentation	IDA	J:88531
Biological Process	GO:0042113	B cell activation	IDA	J:30239
Biological Process	GO:0002344	B cell affinity maturation	IMP	J:49405
Biological Process	GO:0042100	B cell proliferation	IDA	J:64603
Biological Process	GO:0042100	B cell proliferation	IDA	J:33466
Biological Process	GO:0042100	B cell proliferation	IDA	J:42368
Biological Process	GO:0042100	B cell proliferation	IDA	J:91914
Biological Process	GO:0042100	B cell proliferation	IDA	J:106733
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:42368
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:29834
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:94881
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:31951
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:87077
Biological Process	GO:0045022	early endosome to late endosome transport	IDA	J:88531
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	IDA	J:19437
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	IDA	J:88910
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	IDA	J:30239
Biological Process	GO:0016064	immunoglobulin mediated immune response	IDA	J:19552
Biological Process	GO:0016064	immunoglobulin mediated immune response	IDA	J:31133
Biological Process	GO:0016064	immunoglobulin mediated immune response	IDA	J:64281
Biological Process	GO:0016064	immunoglobulin mediated immune response	IDA	J:60916
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	IDA	J:42368
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:29834
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:42368
Biological Process	GO:0050871	positive regulation of B cell activation	IDA	J:30239
Biological Process	GO:0050871	positive regulation of B cell activation	IDA	J:88531
Biological Process	GO:0050871	positive regulation of B cell activation	IDA	J:60916
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:42368
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:33466
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:60916
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:91914
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:64603
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:31133
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:106733
Biological Process	GO:0045807	positive regulation of endocytosis	IDA	J:88531
Biological Process	GO:0050778	positive regulation of immune response	IMP	J:49405
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:42368
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:31951
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:42368
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:94881
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:42368
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:29834
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:31951
Biological Process	GO:0022604	regulation of cell morphogenesis	IMP	J:49405
Biological Process	GO:0002637	regulation of immunoglobulin production	IMP	J:49405