GO Annotations Graph

• Symbol: Hbegf
• Name: heparin-binding EGF-like growth factor
• ID: MGI:96070

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IDA	J:114809
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	IDA	J:114809
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	IDA	J:114809
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	IBA	J:265628
Molecular Function	GO:0048018	receptor ligand activity	IMP	J:177277
Molecular Function	GO:0048018	receptor ligand activity	IMP	J:127663
Molecular Function	GO:0048018	receptor ligand activity	IMP	J:82728
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:82728
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:34905
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2203911
Cellular Component	GO:0005615	extracellular space	IDA	J:51810
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:177277
Cellular Component	GO:0005615	extracellular space	IDA	J:82728
Cellular Component	GO:0005615	extracellular space	ISO	J:34905
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:51810
Biological Process	GO:0001525	angiogenesis	NAS	J:116267
Biological Process	GO:0001832	blastocyst growth	TAS	J:52356
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0016477	cell migration	IMP	J:99026
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:34905
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:82728
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IMP	J:177277
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IMP	J:82728
Biological Process	GO:0051545	negative regulation of elastin biosynthetic process	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:34905
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	IBA	J:265628
Biological Process	GO:0051549	positive regulation of keratinocyte migration	IMP	J:99026
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:34905
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IDA	J:114809
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:82728
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	IMP	J:99026