Grin1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
MGI:95819

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:155856
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0005262	calcium channel activity	IGI	J:17924
Molecular Function	GO:0005262	calcium channel activity	IDA	J:17924
Molecular Function	GO:0005509	calcium ion binding	IDA	J:95556
Molecular Function	GO:0005516	calmodulin binding	IDA	J:95556
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0016595	glutamate binding	ISO	J:164563
Molecular Function	GO:0016595	glutamate binding	ISO	J:155856
Molecular Function	GO:0035254	glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0022849	glutamate-gated calcium ion channel activity	ISO	J:164563
Molecular Function	GO:0016594	glycine binding	ISO	J:155856
Molecular Function	GO:0016594	glycine binding	ISO	J:164563
Molecular Function	GO:0016594	glycine binding	IMP	J:113971
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	IBA	J:265628
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	IGI	J:21285
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0042165	neurotransmitter binding	ISO	J:155856
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:66345
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IDA	J:17924
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:64064
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IDA	J:3203
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:17384
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:77718
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:84354
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:20537
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IDA	J:1333
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:119834
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:1333
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:1333
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:98614
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:66345
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:1333
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:17924
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:21285
Molecular Function	GO:0019902	phosphatase binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:322379
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:116426
Molecular Function	GO:0005515	protein binding	IPI	J:63100
Molecular Function	GO:0005515	protein binding	IPI	J:63100
Molecular Function	GO:0005515	protein binding	IPI	J:304172
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:161179
Molecular Function	GO:0005515	protein binding	IPI	J:200294
Molecular Function	GO:0005515	protein binding	IPI	J:146779
Molecular Function	GO:0005515	protein binding	IPI	J:86846
Molecular Function	GO:0005515	protein binding	IPI	J:145582
Molecular Function	GO:0005515	protein binding	IPI	J:45446
Molecular Function	GO:0005515	protein binding	IPI	J:116055
Molecular Function	GO:0005515	protein binding	IPI	J:37859
Molecular Function	GO:0005515	protein binding	IPI	J:45446
Molecular Function	GO:0005515	protein binding	IPI	J:97815
Molecular Function	GO:0005515	protein binding	IPI	J:174557
Molecular Function	GO:0005515	protein binding	IPI	J:95556
Molecular Function	GO:0005515	protein binding	IPI	J:73508
Molecular Function	GO:0005515	protein binding	IPI	J:37859
Molecular Function	GO:0005515	protein binding	IPI	J:33060
Molecular Function	GO:0005515	protein binding	IPI	J:33060
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:73508
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP	J:139133
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IMP	J:128028
Cellular Component	GO:0009986	cell surface	IDA	J:128028
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:80169
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IMP	J:128028
Cellular Component	GO:0030425	dendrite	IDA	J:197846
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:0044307	dendritic branch	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IDA	J:95556
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:111556
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAS	Reactome:R-MMU-9610352
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAS	Reactome:R-MMU-9610428
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:152455
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:152455
Cellular Component	GO:0030426	growth cone	NAS	J:57578
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:37859
Cellular Component	GO:0016020	membrane	IDA	J:114917
Cellular Component	GO:0016020	membrane	IDA	J:34361
Cellular Component	GO:0016020	membrane	IDA	J:62660
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:155856
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:164563
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IBA	J:265628
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IPI	J:37859
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IPI	J:37859
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928613
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928635
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9610641
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:260353
Cellular Component	GO:0014069	postsynaptic density	IDA	J:96798
Cellular Component	GO:0014069	postsynaptic density	IDA	J:92648
Cellular Component	GO:0014069	postsynaptic density	IDA	J:207532
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:152455
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:152455
Cellular Component	GO:0045211	postsynaptic membrane	NAS	J:92648
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:92648
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:84686
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:73504
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:73065
Cellular Component	GO:0045202	synapse	IDA	J:86846
Cellular Component	GO:0045202	synapse	IDA	J:174557
Cellular Component	GO:0045202	synapse	IDA	J:101438
Cellular Component	GO:0045202	synapse	IDA	J:119025
Cellular Component	GO:0045202	synapse	ISO	J:96464
Cellular Component	GO:0045202	synapse	ISO	J:99780
Cellular Component	GO:0043083	synaptic cleft	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:62660
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:260353
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Cellular Component	GO:0030658	transport vesicle membrane	TAS	Reactome:R-MMU-9610428
Cellular Component	GO:0030658	transport vesicle membrane	TAS	Reactome:R-MMU-9610641
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:62289
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:62289
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:57125
Biological Process	GO:0008306	associative learning	IMP	J:107692
Biological Process	GO:0008306	associative learning	IMP	J:77718
Biological Process	GO:0008306	associative learning	IMP	J:174588
Biological Process	GO:0055074	calcium ion homeostasis	IDA	J:17129
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:107871
Biological Process	GO:0021987	cerebral cortex development	IMP	J:82670
Biological Process	GO:0021987	cerebral cortex development	IMP	J:82670
Biological Process	GO:0021987	cerebral cortex development	IMP	J:64064
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0007268	chemical synaptic transmission	TAS	J:62660
Biological Process	GO:0001661	conditioned taste aversion	IMP	J:100903
Biological Process	GO:0001661	conditioned taste aversion	IMP	J:100903
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:88689
Biological Process	GO:0060079	excitatory postsynaptic potential	IGI	J:86846
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:66345
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:66345
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	IBA	J:265628
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	IDA	J:101438
Biological Process	GO:0007612	learning	IMP	J:115299
Biological Process	GO:0007611	learning or memory	IMP	J:112944
Biological Process	GO:0007616	long-term memory	IMP	J:88689
Biological Process	GO:0060179	male mating behavior	IMP	J:57125
Biological Process	GO:0007613	memory	IMP	J:60770
Biological Process	GO:0007613	memory	IMP	J:60730
Biological Process	GO:0007613	memory	IMP	J:122763
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0006812	monoatomic cation transport	ISO	J:164563
Biological Process	GO:0006812	monoatomic cation transport	IGI	J:21285
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:117103
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:117103
Biological Process	GO:0050905	neuromuscular process	IMP	J:17384
Biological Process	GO:0070050	neuron cellular homeostasis	IMP	J:66345
Biological Process	GO:0070050	neuron cellular homeostasis	IMP	J:66345
Biological Process	GO:0008355	olfactory learning	IMP	J:68059
Biological Process	GO:0008355	olfactory learning	IMP	J:60730
Biological Process	GO:0021586	pons maturation	IMP	J:17384
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:125170
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:125170
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	ISO	J:155856
Biological Process	GO:1902952	positive regulation of dendritic spine maintenance	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:1900149	positive regulation of Schwann cell migration	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:17129
Biological Process	GO:0060134	prepulse inhibition	IMP	J:91878
Biological Process	GO:0018964	propylene metabolic process	IDA	J:184110
Biological Process	GO:0051290	protein heterotetramerization	ISO	J:155856
Biological Process	GO:1903539	protein localization to postsynaptic membrane	IMP	J:83403
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0050770	regulation of axonogenesis	IMP	J:98614
Biological Process	GO:0010646	regulation of cell communication	IMP	J:103934
Biological Process	GO:0048814	regulation of dendrite morphogenesis	IMP	J:98614
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:62289
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:115299
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:119834
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:62289
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	IBA	J:265628
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:84354
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:107871
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:82670
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:119834
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:82670
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:77718
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:66345
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:66345
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0043523	regulation of neuron apoptotic process	IGI	J:57544
Biological Process	GO:0043523	regulation of neuron apoptotic process	IMP	J:112227
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	NAS	J:88689
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	IMP	J:107871
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	IMP	J:17384
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	IMP	J:38582
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	IMP	J:70430
Biological Process	GO:0051963	regulation of synapse assembly	IMP	J:82670
Biological Process	GO:0051963	regulation of synapse assembly	IMP	J:82670
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:41316
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:88689
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:37457
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:37456
Biological Process	GO:0001975	response to amphetamine	IMP	J:109665
Biological Process	GO:0001975	response to amphetamine	IGI	J:170830
Biological Process	GO:0001975	response to amphetamine	IMP	J:133847
Biological Process	GO:0045471	response to ethanol	ISO	J:164563
Biological Process	GO:1905429	response to glycine	ISO	J:164563
Biological Process	GO:0043278	response to morphine	IMP	J:136801
Biological Process	GO:0048511	rhythmic process	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	IMP	J:84354
Biological Process	GO:0035176	social behavior	IMP	J:57125
Biological Process	GO:0001964	startle response	IMP	J:62289
Biological Process	GO:0001964	startle response	IMP	J:62289
Biological Process	GO:0001967	suckling behavior	IMP	J:17384
Biological Process	GO:0001967	suckling behavior	IMP	J:70430
Biological Process	GO:0001967	suckling behavior	IMP	J:38582
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IMP	J:17384
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IMP	J:64064
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:17129
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:17129
Biological Process	GO:0008542	visual learning	IGI	J:38703
Biological Process	GO:0008542	visual learning	IMP	J:119834
Biological Process	GO:0008542	visual learning	IMP	J:41316
Biological Process	GO:0008542	visual learning	IMP	J:62289
Biological Process	GO:0008542	visual learning	IMP	J:37457
Biological Process	GO:0008542	visual learning	IMP	J:108400
Biological Process	GO:0008542	visual learning	IMP	J:62289

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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