GO Annotations Graph

• Symbol: Grik2
• Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
• ID: MGI:95815

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005234	extracellularly glutamate-gated ion channel activity	ISO	J:164563
Molecular Function	GO:0008066	glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	IMP	J:114811
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	IDA	J:287030
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IBA	J:265628
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IMP	J:60965
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IDA	J:696
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IDA	J:109768
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IMP	J:96594
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IGI	J:97340
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IMP	J:79143
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IMP	J:97340
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IDA	J:78109
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IMP	J:79143
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IMP	J:46932
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IGI	J:696
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	IMP	J:52041
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA	J:148310
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA	J:148310
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEP	J:148310
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP	J:148310
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA	J:148310
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:114811
Molecular Function	GO:0005515	protein binding	IPI	J:174557
Molecular Function	GO:0005515	protein binding	IPI	J:174557
Molecular Function	GO:0005515	protein binding	IPI	J:85342
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0000149	SNARE binding	ISO	J:155856
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA	J:265628
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA	J:265622
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA	J:265622
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP	J:265622
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP	J:265622
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA	J:265622
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA	J:46932
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP	J:46932
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:148310
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:148310
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:148310
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:148310
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:148310
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:238521
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:238521
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:238521
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:238521
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	EXP	J:265622
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:265622
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:265622
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:265622
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IMP	J:265622
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:46932
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IMP	J:46932
Cellular Component	GO:0008328	ionotropic glutamate receptor complex	ISO	J:155856
Cellular Component	GO:0008328	ionotropic glutamate receptor complex	IC	J:79143
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	IBA	J:265628
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	IPI	J:85342
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	IPI	J:123244
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	IPI	J:85342
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	IPI	J:123244
Cellular Component	GO:0016020	membrane	IDA	J:85342
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:238521
Cellular Component	GO:0097471	mossy fiber rosette	IMP	J:238521
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:238521
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:238521
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40245
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IDA	J:174557
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:105519
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:238521
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:238521
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:238521
Cellular Component	GO:0045211	postsynaptic membrane	IMP	J:238521
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:238521
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:238521
Cellular Component	GO:0045211	postsynaptic membrane	IMP	J:238521
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:238521
Cellular Component	GO:0042734	presynaptic membrane	IBA	J:265628
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:105519
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:97340
Cellular Component	GO:0045202	synapse	TAS	J:114811
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:174557
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0001662	behavioral fear response	IMP	J:98109
Biological Process	GO:0007268	chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IGI	J:114338
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:114338
Biological Process	GO:0120169	detection of cold stimulus involved in thermoception	IMP	J:287030
Biological Process	GO:0060079	excitatory postsynaptic potential	IGI	J:97340
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:111580
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:105519
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:52041
Biological Process	GO:0060080	inhibitory postsynaptic potential	IGI	J:60965
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:79143
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:60965
Biological Process	GO:0060080	inhibitory postsynaptic potential	IGI	J:66021
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:104051
Biological Process	GO:0050804	modulation of chemical synaptic transmission	ISO	J:164563
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:57544
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	IGI	J:97340
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:155856
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:57544
Biological Process	GO:0019228	neuronal action potential	IMP	J:107777
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0050806	positive regulation of synaptic transmission	ISO	J:164563
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IGI	J:97340
Biological Process	GO:0043113	receptor clustering	ISO	J:155856
Biological Process	GO:0046328	regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:104051
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:98109
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:98109
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:89599
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:91763
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:60965
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:46392
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:696
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:107790
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:79143
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:96594
Biological Process	GO:0042391	regulation of membrane potential	IDA	J:78109
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:104051
Biological Process	GO:0042391	regulation of membrane potential	IDA	J:696
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	ISO	J:164563
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	IMP	J:91763
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IBA	J:265628
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IMP	J:96594
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IMP	J:46932